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Dec 1, 2017 · Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology ...
Aug 14, 2023 · Substantial gaps remain in the comprehensive understanding of the pathogenesis of dengue virus (DENV) infections. In large part, this limitation is related to the lack of a suitable animal model of disease [ 1 ]. Rhesus monkeys develop RNAemia and viremia similar in a pattern to humans after DENV challenge but do not develop clinical disease.
Figure 1: Dengue viral infection. (A) A person is infected with the dengue virus when an infected mosquito bites the person’s skin. (B) The dengue virus infects the Langerhans cells, a type of ...
Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be ...
Dec 7, 2023 · The weakness of current DHF risk maps Host serological profile and virus genetic diversity. Dengue is caused by four distinct serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4) . Once a person is infected with one serotype, they develop lifelong immunity to that specific serotype but remain susceptible to the other serotypes.
Jan 6, 2021 · By contrast, 81 countries and territories had no dengue data in 2017 (Fig. 1A and Supplementary Table 2). Moreover, the GBD 2017 reported the first dengue cases in South Africa and Namibia, with estimated incidence rates per 100 000 population of 121.2 (45.2–263.8) and 9856.9 (6209.5–14,576.6), respectively (Supplementary Table 3).
Dengue is caused by a type of flavivírus, which is an enveloped virus of spherical geometry. Nowadays, it is one of the diseases with the highest incidence in Brazil, reaching the population of all states, regardless of social class. Several papers address the molecular aspects of infection of human cell by the viruses, which are reviewed in ...
