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  1. Adverse effects: Doxycycline can cause GI adverse effects, photosensitivity, and esophageal irritation, which can be mitigated using strategies noted above. Long-term doxycycline use may increase the risk of developing an antibiotic-resistant infection. The potential long-term effects of doxy-PEP use are not known at this time.

  2. Feb 4, 2023 · Antibiotic therapy through short-term or repeated long-term prescriptions can have several damaging effects on the normal microbiota of the gastrointestinal tract. Changes in microbiota could be multiple including decreased diversity of species in gut microbiota, changed metabolic activity, and the occurrence of antibiotic-resistant strains.

  3. Jan 23, 2017 · One RCT found 3 weeks of doxycycline beneficial in patients with polyps but follow up was short (<3 months); RCTs of prolonged macrolide therapy have produced mixed results, and most show no benefit after cessation of therapy. Longterm antibiotic therapy may produce side effects and select increasingly resistant flora.

  4. Feb 12, 2024 · increased sensitivity of the skin to sunlight. increased thirst. indigestion. inflammation of the joints. joint or muscle pain. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. loss of appetite. lower back or side pain. nausea.

  5. Feb 12, 2024 · lower back or side pain. nausea. numbness or tingling of the face, hands, or feet. pain in the stomach, side, or abdomen, possibly radiating to the back. painful or difficult urination. pale skin. pinpoint red spots on the skin. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue.

  6. Jan 13, 2022 · To investigate the long term effects of antibiotics on the healthy state microbial composition, the antibiotics amoxicillin (n = 6; Cochetière et al., 2005), ciprofloxacin (n = 3; Les Dethlefsen et al., 2008), and cefprozil (n = 24; Raymond et al., 2016) were administered to healthy individuals. These studies reported changes in microbial ...

  7. Jan 15, 2021 · Effects of longterm antibiotics are not completely understood. Antibiotics may offer both antibacterial and anti‐inflammatory effects ( Martinez 2008 ), and therefore may reduce both bacterial load and inflammation as a result of exacerbations from bacteria, viruses, and environmental pollution.

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