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False-Positive Serological Test Results for Lyme Disease in a Patient with Acute Herpes Simplex Virus Type 2 Infection, Clinical Infectious Diseases, 41, 12, (1826-1827), (2005). https://doi.org ...
False positive EIA tests (not confirmed by the immunoblot test) can be caused by cross reactions in cases of syphilis, some other bacterial infections and Epstein Barr virus (EBV) infection.[8] The possible reasons for a negative test in a person who genuinely has Lyme disease are:
Jan 14, 2024 · Limitations and potential false positives/negatives. The ELISA test is a commonly used diagnostic tool for Lyme disease, but it has some limitations and can produce false positive and false negative results. Some of these limitations include: Sensitivity. The sensitivity of ELISA tests can be low, especially during the early stages of Lyme disease.
The Lyme disease IgM immunoblot is valuable in the diagnosis of early Lyme disease in children. However, a positive IgM and a negative IgG in a child with a long duration of symptoms, late manifestations, or nonspecific clinical presentation is likely a false positive result for Lyme disease. Clinicians should only obtain Lyme testing in ...
Between 2000 and 2005, a “Dot Blot” test for urine antigens against Lyme disease was offered, claiming a 97% “true positive rate,” although this term does not have a clear meaning in public health terms. 9 An independent evaluation conducted in 2001 ran the test five times for the same 10 healthy subjects (i.e., 50 tests) and found that ...
Feb 3, 2022 · Unfortunately, at present, the interpretation of the obtained results using serological tests is problematic due to the generation of a large percentage of false positives or false negatives [6,9,11,12,13,14,15]. For this reason, the diagnosis should be based mainly on the clinical picture and history of tick exposure of the patient.
Oct 5, 2023 · So far, the problem of Lyme disease cross-reactions has not been studied by many scientists; only a few comprehensive studies have been carried out to identify a wide range of potential disease/pathogen entities causing false-positive test results and to characterize cross-reactive B. burgdorferi s.l. proteins [60,83,109,123].
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