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Jul 12, 2023 · Clarithromycin isn't generally recommended in pregnant females due to the potential risk for problems (e.g., heart problems, cleft palate) seen in animal studies. The risk of harm to human babies isn't completely clear. A 2021 human study found that babies born to pregnant
Jan 2, 2013 · The antibiotic clarithromycin has been associated with fetal loss in animals and a study has found a doubling in the frequency of miscarriages among women using clarithromycin in pregnancy. The aim of the study was to investigate whether clarithromycin use in early pregnancy was associated with an increased risk for miscarriages and major ...
Aug 8, 2008 · The renal clearance of clarithromycin is, however, relatively independent of the dose size and approximates the normal glomerular filtration rate. The major metabolite found in urine is 14-OH clarithromycin, which accounts for an additional 10% to 15% of the dose with either a 250 mg or a 500 mg tablet administered every 12 hours.
Methods and results: In a detailed literature search, we found 15 women, five men, and one boy meeting our search criteria. Among the 17 adults with reported clarithromycin dose and concurrent QTc interval measurement, we found no statistically significant relationship between clarithromycin dose and QTc interval duration.
Oct 12, 2012 · Synopsis Clarithromycin is a broad spectrum macrolide antibacterial agent active in vitro and effective in vivo against the major pathogens responsible for respiratory tract infections in immunocompetent patients. It is highly active in vitro against pathogens causing atypical pneumonia (Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella spp.) and has similar activity to other ...
Feb 18, 2020 · Possible ischemic hepatitis from heart failure (ejection fraction = 10%); heavy alcohol use; started ceftriaxone concomitant with clarithromycin. Extensive workup found no other metabolic or infectious causes of acute liver failure. No serologic testing for hepatitis E. Took four times normal initial dose of clarithromycin.
Jan 29, 2022 · They found 17.5%, 14.1%, and 34.9% of isolates to be resistant to clarithromycin, levofloxacin, and metronidazole, respectively. Moreover, they demonstrated significant associations between outpatient levofloxacin and long-acting macrolide use and resistance to levofloxacin ( p = 0.0013) and clarithromycin ( p = 0.036), respectively.
