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  1. Oct 17, 2023 · The ventral tegmentum is one of these areas. The ventral tegmentum is composed of a number of neurons that are located in the midbrain. They are found on the floor of the brain close to the midline brain. The ventral tegmentum plays a significant role in a number of functions, including those associated with reward.

  2. Fig. 3. Reward and stress activate VTA dopamine neurons, increasing extracellular dopamine in the mPFC and NAcSh. Both rewarding and stressful stimuli induce dopaminergic increases in ventral tegmental area (VTA) projection targets, namely, the medial prefrontal cortex (mPFC) and nucleus accumbens shell (NAcSh), to a similar degree.

  3. The dopaminergic pathway mostly involved in reward is the so-called mesolimbic system, which is formed by projections of midbrain dopamine neurons of the ventral tegmental area (VTA) to the striatum, prefrontal cortex, amygdala, hippocampus, and many other structures of the limbic system.

  4. Sep 14, 2023 · The brain's reward system is a network of structures responsible for pleasure, motivation, and reinforcement learning. Central to this system are the Ventral Tegmental Area (VTA) and the Nucleus Accumbens (NAc). When a rewarding stimulus is perceived, dopamine is released from the VTA, acting on the NAc, leading to feelings of pleasure. Dysfunctions in this pathway can underlie addiction and ...

  5. Dec 5, 2019 · The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA ...

  6. Dec 12, 2014 · The ventral tegmental area (VTA) in the brain’s reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression. These neurons ...

  7. Feb 12, 2021 · The ventral tegmental area (VTA) is a subcortical structure that plays a pivotal role in reward processing, learning and memory. Despite the significant interest in this nucleus in cognitive neuroscience, there are currently no available, anatomically precise VTA atlases derived from 7 T MRI data that cover the full region of the VTA.

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