Search results
Specialty. Hematology. Von Willebrand disease ( VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.
Symptoms of von Willebrand disease can include bruising easily, very heavy or long menstrual periods, prolonged and excessive bleeding after a cut, injury, medical procedure or childbirth. A specialist doctor can diagnose you with Von Willebrand disease by referring you for special blood tests. Your treatment depends on the type of Von ...
La maladie de Willebrand est une maladie hémorragique héréditaire causée par un déficit ou par un défaut de fonctionnement d’une protéine du sang appelée le facteur Willebrand (VWF). Le facteur Willebrand a 2 grands rôles dans l’hémostase : Lorsqu’il n’y a pas suffisamment de VWF dans le sang ou qu’il ne fonctionne pas ...
Nov 18, 2014 · Progress in the diagnosis of type 1 VWD during the last few years has focused on 1) improvements in laboratory testing, 2) alternative tests of platelet-VWF–binding activity that do not require ristocetin, 3) more extensive testing for VWF binding to collagen, 4) incorporating genetic testing into laboratory diagnosis, and 5) development and validation of quantitative bleeding assessment ...
Jul 23, 2023 · The most common symptoms of von Willebrand disease in decreasing frequency include: Heavy or prolonged menstrual bleeding (previously called menorrhagia) Frequent and easy bruising (from minimal trauma) Bleeding in the throat and mouth. Frequent or hard-to-stop nosebleeds.
Synopsis. Von Willebrand disease (VWD) is a common bleeding disorder, affecting males and females equally, that often manifests in mucosal bleeding. VWD can be secondary to a quantitative (Type 1 and Type 3) or qualitative (Type 2) defects in Von Willebrand factor.
Etiology. VWD is caused by mutations in the VWF gene (12p13.3). The anomalies responsible for type 1 VWD generally lead to intracellular retention or rapid clearance of VWF from the circulation. However, families have been described in which no mutations in the VWF gene have been detected indicating that other genetic factors are also implicated.
