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May 6, 2024 · Ampicillin/sulbactam is still recommended even in case of resistance to ampicillin/sulbactam, as defined based on CLSI breakpoints . Optimal dosing regimen and adjustment for kidney function not yet clear.
May 20, 2024 · The drug susceptibility results indicated that the bacterium was sensitive to tigecycline, amikacin, gentamicin, and tobramycin, and showed an intermediate response to cefoperazone-sulbactam (Table 1). Consequently, cefoperazone-sulbactam (30mg/kg IV q8h, in a 1:1 ratio) and amikacin (7.5mg/kg IV q12h) were administered instead.
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May 15, 2024 · Use of high-dose ampicillin-sulbactam with at least one other agent is suggested, a recommendation that preceded the approval of SUL-DUR. This practice considers the anticipated high bacterial burden of CRAB due to delays in initiation of effective antimicrobial therapy, and potential of this organism to develop resistance to a single agent ...
6 days ago · Find information on Ampicillin/sulbactam (Unasyn) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more.
5 days ago · For mildly to moderately severe community-acquired infections, the guidelines recommend agents with a narrower spectrum of activity that are not typically used for nosocomial infections, such as ampicillin/sulbactam, cefazolin or cefuroxime plus metronidazole, ticarcillin/clavulanate, ertapenem, and quinolones plus metronidazole.
May 6, 2024 · Inoculum effect was found for cefazolin and ampicillin/sulbactam, but not cefotaxime, ceftriaxone, imipenem and meropenem: 31: Prospective cohort Multicentre 2013–2015 South Korea: Patients with MSSA bacteraemia (N = 303) CzIE-positive group (n = 61) CzIE-negative group (n = 242) Characteristics of CzIE-positive isolates
May 16, 2024 · The pharmacokinetics of ampicillin and sulbactam in pediatric patients receiving UNASYN are similar to those observed in adults. Immediately after a 15-minute infusion of 50 to 75 mg UNASYN/kg body weight, peak serum and plasma concentrations of 82 to 446 mcg ampicillin/mL and 44 to 203 mcg sulbactam/mL were obtained.
