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The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company (ABC) on September 25, 2005, and concluded on May 15, 2006. The season was produced by Touchstone Television in conjuction with Shondaland production company and The Mark Gordon Company, the showrunner being Shonda Rhimes. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, ... Wikipedia