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Apr 29, 2024 · Nifurtimox^ and Eflornithine† combination (NECT) < 6 years old or weight < 20 kg >5 WBC/uL, or trypanosomes: Nifurtimox 15 mg/kg/day orally in three doses x 10 days and Eflornithine 400 mg/kg/day, IV, in two 2-hour infusions (each dose diluted in 250mL of water for injection) x 7 days.
Apr 27, 2024 · The two main drugs used for the treatment of Chagas disease are benznidazole and nifurtimox. These medications are most effective in the acute phase of the infection, but they can also be used in the chronic phase. Benznidazole and nifurtimox work by killing the parasite that causes Chagas disease.
- Alexander Muller
May 8, 2024 · African trypanosomiasis, also known as sleeping sickness, is a protozoan parasitic disease caused by the genus Trypanosoma. 1. Pathophysiology. African trypanosomiasis is caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, transmitted to humans by the bite of an infected tsetse fly (Glossina species).
Apr 27, 2024 · Yes, there have been advancements in drug therapies for Chagas disease. Some of the new drugs under investigation include benznidazole and nifurtimox, which have shown efficacy in treating the acute phase of the disease.
2 days ago · Anti-parasitic treatment is limited to the nitroheterocyclic drugs, nifurtimox and benznidazole (BZ). Both have long dosing schedules and can cause significant toxicity 7 , 8 .
May 3, 2024 · The electrochemical behavior of Nifurtimox, the anti-chagasic reference drug, was evaluated under the same experimental conditions. Nifurtimox also showed this reversible reduction process to generate the nitro anion radical, which agrees with their principal mechanism of action.
May 1, 2024 · They said the last mile would be the hardest. The challenge to eliminate human African trypanosomiasis caused by Trypanosoma brucei gambiense (gHAT) could have entered that most difficult stretch. The fifth stakeholders’ meeting on gambiense and rhodesiense HAT, convened by the World Health Organisation (WHO) in Geneva (7–9 June 2023 ...
