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May 9, 2024 · Neuraminidase (NA) is the second most abundant surface glycoprotein on influenza viruses, and antibodies to NA have been shown to be effective against influenza infection. In this study, we generated a monoclonal antibody (mAb), named FNA1, directed toward N1 NAs.
3 days ago · Catching the drift of influenza neuraminidases. Examining the recent evolution of an influenza protein helps to understand how the immune system responds to its different variants. Neuraminidase is an enzyme present at the surface of the influenza virus. Changes in certain amino acids (red), in particular those closer to the enzymatic site, are ...
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May 20, 2024 · In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.
May 13, 2024 · Wild aquatic birds are the original reservoir of influenza A viruses, which are categorised by the antigenic properties of their hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins....
May 9, 2024 · Gao, J. et al. Antigenic drift of the influenza A(H1N1)pdm09 virus neuraminidase results in reduced effectiveness of A/California/7/2009 (H1N1pdm09)-specific antibodies. MBio 10, (2019).
May 11, 2024 · The neuraminidase is expressed at a lower abundance than the haemagglutinin on the virus surface but does elicit a robust antibody response. This review aims to compile the current information on haemagglutinin and neuraminidase epitopes and immune escape mutants of H5 and H7 highly pathogenic avian influenza viruses.
May 15, 2024 · Antigenic drift, a minor change in the antigenicity of IAV caused by site mutations of surface glycoprotein (either hemagglutinin or neuraminidase), can lead to annual seasonal epidemics ( Webby and Webster, 2001 ), while antigenic shift is to blame the HA or NA recombination events and can generally cause a virus pandemic ( Gao et al., 2013 ).
