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1. www.nature.com › articles › s41564/024/01705-xPersonalized bacteriophage therapy outcomes for 100 ... - Nature

   www.nature.com › articles › s41564/024/01705-x

   Jun 4, 2024 · Analysis of 100 consecutive personalized bacteriophage therapy cases supports the use of personalized and sometimes pre-adapted, bacteriophage preparations, often in combination with...

   • Bacteriophage defends murine gut from Escherichia coli ...

     Nature Communications - Authors profile the antimicrobial...

   • Personalized bacteriophage therapy for difficult-to-treat ...

     A real-world study of 100 diverse cases facilitated by a...

2. www.nature.com › articles › s41467/024/48560-2Bacteriophage defends murine gut from Escherichia coli ...

   www.nature.com › articles › s41467/024/48560-2

   Jun 4, 2024 · Nature Communications - Authors profile the antimicrobial activity of an Escherichia coli bacteriophage (in vivo and in vitro), isolated from chicken faeces.

3. www.nature.com › articles › s41564/024/01712-yPersonalized bacteriophage therapy for difficult-to-treat ...

   www.nature.com › articles › s41564/024/01712-y

   Jun 4, 2024 · A real-world study of 100 diverse cases facilitated by a single centre for individualized bacteriophage therapy demonstrates feasibility and provides new hope for refractory and resistant ...

4. mdpi-res.com › d_attachment › microorganismsBenefits and Challenges of Applying Bacteriophage Biocontrol ...

   mdpi-res.com › d_attachment › microorganisms

   Jun 7, 2024 · In this review, the bacteriophage life cycle and associated characteristics that highlight their potential as biocontrol agents is outlined. Additionally, the opportunities for the application of bacteriophage biocontrol in various industries throughout the consumer

5. link.springer.com › protocol › 10Bacteriophages Isolation and Efficacy Testing | SpringerLink

   link.springer.com › protocol › 10

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   Jun 19, 2024 · To verify the purity, titration, and propagation (amplification) of phages, we describe, in detail, the commonly used methods such as streaking, spot-testing, and soft agar overlay. Lastly, we briefly discuss recommended tests that should be performed to ensure purity of the isolated phage.

6. www.ncbi.nlm.nih.gov › pmc › articlesBacteriophage defends murine gut from Escherichia coli ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 4, 2024 · Abstract. Bacteriophage are sophisticated cellular parasites that can not only parasitize bacteria but are increasingly recognized for their direct interactions with mammalian hosts. Phage adherence to mucus is known to mediate enhanced antimicrobial effects in vitro.

7. People also ask

   Can bacteriophage therapy help refractory bacterial infections?

   • A real-world study of 100 diverse cases facilitated by a single centre for individualized bacteriophage therapy demonstrates feasibility and provides new hope for refractory and resistant bacterial infections. After a controversial start more than a century ago 1, bacteriophage therapy is still in use today.

   Personalized bacteriophage therapy for difficult-to-treat ... - Nature

   www.nature.com/articles/s41564-024-01712-y

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   Can bacteriophage therapy be used in real life?

   • Nevertheless, the data that can be gathered from such cases are enormously valuable. Writing in Nature Microbiology, Pirnay et al. 2, based at the Queen Astrid Military Hospital in Belgium, present 100 consecutive cases of bacteriophage therapy in several countries, which is the largest real-world clinical dataset described so far (Fig. 1 ).

   Personalized bacteriophage therapy for difficult-to-treat ... - Nature

   www.nature.com/articles/s41564-024-01712-y

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   Does bacteriophage uptake affect phage therapy?

   • Bichet, M. C. et al. Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy. iScience 24, 102287 (2021). Roach, D. R. et al. Synergy between the host immune system and bacteriophage is essential for successful phage therapy against an acute respiratory pathogen.

   Bacteriophage defends murine gut from Escherichia coli invasion via mu…

   www.nature.com/articles/s41467-024-48560-2

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   How many cases of bacteriophage therapy are there?

   • Writing in Nature Microbiology, Pirnay et al. 2, based at the Queen Astrid Military Hospital in Belgium, present 100 consecutive cases of bacteriophage therapy in several countries, which is the largest real-world clinical dataset described so far (Fig. 1 ). Fig. 1: One hundred cases of individualized bacteriophage therapy.

   Personalized bacteriophage therapy for difficult-to-treat ... - Nature

   www.nature.com/articles/s41564-024-01712-y

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   Should bacteriophage targeting be more precise?

   • Clarity is still needed around both dosing (that is, how much phage to give and how often) and effect (benefit) size to understand the statistical power required. Nevertheless, precise bacteriophage targeting of bacteria causing severe infection is an exciting prospect for the future.

   Personalized bacteriophage therapy for difficult-to-treat ... - Nature

   www.nature.com/articles/s41564-024-01712-y

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   Can bacteriophages improve the eradication rate of targeted bacteria?

   • In conclusion, we present evidence that the use of bacteriophages in addition to standard-of-care antibiotics can significantly improve the eradication rate of targeted bacteria in this patient population. These data can be useful for designing future controlled clinical trials that are urgently needed to assist the BT field.

   Personalized bacteriophage therapy outcomes for 100 consecutive case…

   www.nature.com/articles/s41564-024-01705-x

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8. www.tandfonline.com › doi › fullFull article: Bacteriophage-based bioassays: an expected ...

   www.tandfonline.com › doi › full

   Jun 20, 2024 · The article reviews the current landscape of diagnostic technologies, identify gaps and highlight emerging possibilities demonstrates a comprehensive approach to advancing clinical diagnosis of microbial pathogens and covers an overview of existing phage-based bioassays.