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  1. May 29, 2024 · Gerhard J. Domagk uses a chemically synthesized antimetabolite, Prontosil, to kill Streptococcus in mice. It is later shown that Prontosil is hydrolyzed in vivo to an active compound, sulfanilamide. One of the first patients to be treated with Protonsil was Domagk's daughter who had a streptococcal infection that was unresponsive to other ...

    • Karen Yee
    • 2018
  2. en.wikipedia.org › wiki › AntibioticAntibiotic - Wikipedia

    1 day ago · The first sulfonamide and the first systemically active antibacterial drug, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany, for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.

  3. May 23, 2024 · Afterwards, Domagk became a researcher and clinician at the University of Munster. It was there that he developed the seeds of a major breakthrough when he utilized white blood cells coupled with a staph pathogen in his examination of the vertebrate immune system.

  4. 16 hours ago · In the realm of science, Gerhard Domagk, a German pathologist and bacteriologist, was awarded the Nobel Prize in Physiology or Medicine in 1939 for his discovery of the antibacterial effects of prontosil, a breakthrough in medical treatment.

  5. May 9, 2024 · Prontosil, a sulfonamide prodrug found by Gerhard Domagk, a Bayer bacteriologist who utilized it to save his little girl’s appendage from removal, finally replaced Salvarsan. Since the sulfa drugs were roused by colors used to precisely label bacterial cells, Domagk and colleagues were essentially continuing Paul Ehrlich’s research.

  6. May 10, 2024 · Before 1938, toxicological testing of new drugs before marketing had not been mandatory. A year earlier, Dr. Gerhard Domagk, a German pathologist and bacteriologist, had discovered that the industrial dye prontosil protected mice from streptococcal infections . Sulfanilamide, a drug used for the treatment of streptococcal infection, proved to ...

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  8. May 26, 2024 · The research was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft) and a European Medicines Agency service contract. Dr. Schönborn was supported by the ASH Global Research Award from the American Society of Hematology and by the Gerhard Domagk Research Program through the Medical University of Greifswald. Dr.

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