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  1. Jun 6, 2024 · We demonstrate the effectiveness of these tools by disrupting the intracellular life cycle using CRISPRi to deplete the sca2 virulence factor. These tools will be crucial for building a more comprehensive and detailed understanding of rickettsial biology and pathogenesis.

  2. 6 days ago · Booster vaccination could significantly reduce all-cause mortality within 28 days for patients with disease onset to hospitalization ≤5 days (IPTW-adjusted HR 0.61, 95%CI 0.50–0.74), CCI < 3 (IPTW-adjusted HR 0.64, 95%CI 0.53–0.78), and without immunosuppression status (IPTW-adjusted HR 0.84, 95%CI 0.77–0.91).

  3. Jun 16, 2024 · The objective of this approach was to assess the immunogenicity and efficacy of a mucosal S protein vaccine in both primary and booster immunization in mice, as well as to investigate the feasibility of this combination as a vaccine booster following two doses of inactivated vaccines.

  4. Jun 19, 2024 · Live-Attenuated Vaccines (LAVs) stimulate robust mucosal and cellular responses and have the potential to protect against Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (HMPV), the...

  5. Jun 10, 2024 · A portion of anti-RBD antibody clones that develops after a primary series or booster dose of ancestral strain-based COVID-19 vaccination exhibit broad neutralization against Omicron variants.

  6. Jun 5, 2024 · This new Clec9A targeting technology may potentially address the issue of waning COVID-19 vaccine immunity, and eliminate the need for repeated booster jabs, particularly for people aged 60 and over, medically vulnerable individuals and their caregivers.

  7. Jun 8, 2024 · Rickettsia asembonensis is a potential emerging pathogen that was previously detected in humans, animals, and a variety of arthropods. While its pathogenicity in humans remains unclear, it poses a potential public health threat.

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