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Oct 30, 2023 · The substantia nigra, also known as the black nucleus, is a large gray matter structure of the mesencephalon or midbrain (middle brain). It gets its name from its dark appearance on the cross-sections of the brain ( Latin for 'Black substance').
Oct 4, 2022 · The substantia nigra is a motor nucleus located in the basal ganglia of the midbrain. This brain structure contributes to the body's cognitive and motor functions by sending...
Aug 21, 2020 · We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples.
Sep 18, 2020 · The authors found that areas of reduced signal were localized in the posterolateral substantia nigra in early Parkinson’s disease and RBD, whereas in progressing Parkinson’s disease, the loss of signal extended into the medial and anterior areas.
Oct 24, 2022 · The substantia nigra (SN) is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. Projections from the SN to the putamen, called the nigrostriatal pathway, are critically involved in the motor deficits obs ….
Jan 25, 2024 · Monosynaptic cerebellar projections to the substantia nigra pars compacta (SNc) increase the activity of SNc neurons and striatal dopamine levels.
Jun 8, 2021 · This review presents up-to-date imaging applications in the substantia nigra and its related structures used in Parkinson disease and other parkinsonian syndromes, assesses their usefulness, and discusses multimodal approaches that might further improve the diagnosis and treatment of this disease.
