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  1. Sep 16, 2024 · RTS,S and R21 are subunit vaccines that target the pre-erythrocytic stages of infection by Plasmodium falciparum (Pf), the deadliest human-infective malaria parasite. Both employ a fusion of the immunodominant epitopes of the Pf circumsporozoite protein (PfCSP) with a surface antigen of the hepatitis B virus, and are formulated with the AS01 ...

  2. Sep 1, 2024 · This system is the most prevalent secretion system in Gram-negative bacteria. These proteins are compelling vaccine candidates due to their demonstrated protective role in current licensed...

  3. 1 day ago · The nine-valent ExPEC9V bioconjugate vaccine, targeting nine separate strains of E. coli and also known as VAC52416, is currently being compared to placebo in a phase 3 trial involving...

  4. 1 day ago · The isocyanoterpene (ICT) family of sponge-derived natural products has shown potent antibacterial, antifungal, and antimalarial activity. Among the ICTs, the kalihinol subfamily, including kalihinols A and B, has shown activity against both drug-sensitive and drug-resistant Plasmodium falciparum isolates.

  5. 3 days ago · A trophozoite feeds on the haemoglobin and forms a granular pigment called haemozoin. Unlike those of other Plasmodium species, the gametocytes of P. falciparum are elongated and crescent-shaped, by which they are sometimes identified.

  6. Sep 19, 2024 · The aim of this chapter is to provide a comprehensive exploration of the field of vaccines, with a specific focus on human vaccines. It covers a range of topics, from fundamental concepts of immunity to the evolution of vaccine development approaches, as well as the challenges and advancements within this domain.

  7. 1 day ago · The resurgence of the Nipah virus (NiV) in 2023 has raised concerns for another potentially severe pandemic, given its history of high mortality from previous outbreaks. Unfortunately, no therapeutics and vaccines have been available for the virus. This study used immunoinformatics and molecular modeling to design and evaluate a multi-epitope subunit vaccine targeting NiV. The designed vaccine ...

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