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Aug 4, 2020 · The Warburg effect is generally thought to confer growth advantages to tumor cells including the rapid supply of ATP, amino acids for protein synthesis, nucleic acids for DNA duplication, and lipids for cell biomembrane synthesis, which may be needed in cell proliferation.
Nov 21, 2023 · Metrics. In 1923, Otto Warburg published his landmark study, in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His...
- Craig B. Thompson
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Feb 3, 2020 · 448 Citations. 295 Altmetric. Metrics. We are approaching the 100th anniversary of Otto Warburg’s first description of the metabolic phenotype bearing his name—a propensity for tumours to...
- Ralph J. DeBerardinis, Navdeep S. Chandel
- 2020
May 5, 2009 · In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.”
- Matthew G. Vander Heiden, Lewis C. Cantley, Craig B. Thompson
- 10.1126/science.1160809
- 2009
- 2009/05/05
Mar 1, 2024 · Warburg effect can promote the upregulation of the expression of HK, GLUT, LDH, PK and 3-phosphoinositide-dependent protein kinase 1 (PDK1), improve the tolerance of tumor cells to hypoxia conditions, and then promote the invasion and metastasis of malignant tumors.
Dec 19, 2017 · The Warburg effect may be an evolutionary conserved mechanism for balancing ATP production with biomass production. Focus on metabolic regulation in cancer provided a unifying theory for understanding interactions between prominent oncoproteins and tumor suppressors that deregulate glycolysis.
Apr 14, 2011 · Otto Warburg was a pioneering biochemistry researcher who made substantial contributions to our early understanding of cancer metabolism. Warburg was awarded the Nobel Prize in Physiology or...
