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- rarediseases.info.nih.gov
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SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones).
Mar 2, 2020 · SAPHO syndrome is a rare disorder with a wide range of possible symptoms. Some common symptoms include blisters, acne, and inflammation of the joints and bones.
Jan 21, 2022 · The SAPHO syndrome was given its acronymic name based upon the presence of synovitis, acne, pustulosis, hyperostosis, and osteitis in the patients described in early reports. It is a rare inflammatory disorder of bone, joints, and skin, which was first described as a syndrome in 1987 .
SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes. These diseases share some clinical, radiologic, and pathologic characteristics. An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972.
May 21, 2024 · The SAPHO syndrome is an acronym that refers to a rare syndrome that is manifested by a combined occurrence of 2: S: synovitis. A: acne. P: pustulosis. H: hyperostosis. O: osteitis. Epidemiology. SAPHO classically tends to present in young to middle-aged adults. Presentation in the pediatric population is not uncommon.
SAPHO syndrome is suspected when a patient presents with a pustular skin disease in association with rheumatic pain. Magnetic resonance imaging ( MRI scan) shows inflammation of the bone marrow or joints at characteristic sites such as the collar bone, breast bone, pelvis, heel, and lower jaw.
- www.ncbi.nlm.nih.gov
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- › v.9(4); 2023
Dec 26, 2023 · The clinical syndrome including synovitis, acne, (palmoplantar) pustulosis and hyperostosis osteitis, also known as synovitis acne pustulosis hyperostosis osteitis (SAPHO), constitutes a rare systemic inflammatory disease of currently unknown aetiopathology. 1–4 SAPHO is characterised by osteoarticular and dermatological features following a ...
- www.ncbi.nlm.nih.gov
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- › v.38(6); 2021 Dec
Jul 23, 2020 · Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a disease characterised by dermatological and osteoarticular symptoms and was introduced by Chamot et al. in 1987. The diagnostic criteria for SAPHO syndrome were developed by Kahn et al. in 1994.
- link.springer.com
- › Rheumatology International
Oct 27, 2023 · This review provides an overview of SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), a rare autoinflammatory disease that primarily affects.
SAPHO syndrome encompasses a wide spectrum of anomalies characterized by variable combinations of osteoarticular and cutaneous manifestations of varying degrees of severity. The onset of bone and joint pain, stiffness and swelling is most often insidious.
