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  1. Its original meaning in English, “highly injurious or destructive,” usually applies to things (“pernicious apathy,” “pernicious effects”) and medical conditions (“pernicious fever,” “pernicious anemia”). When applied to people, pernicious means “wicked.”

  2. having a very harmful effect or influence: The cuts in government funding have had a pernicious effect on local health services. SMART Vocabulary: related words and phrases. Dangerous and harmful. adverse conditions. adverse effect. adverse publicity. adverse reaction. deleteriously. destabilizing. destructively. destructiveness. inimically.

  3. Synonyms for PERNICIOUS: harmful, dangerous, detrimental, damaging, adverse, bad, poisonous, deleterious; Antonyms of PERNICIOUS: benign, harmless, beneficial, innocuous, innocent, useful, safe, inoffensive.

  4. having a very harmful effect or influence: The cuts in government funding have had a pernicious effect on local health services. SMART Vocabulary: related words and phrases. Dangerous and harmful. adverse. adverse conditions. adverse effect. adverse publicity.

  5. Pernicious definition: causing insidious harm or ruin; ruinous; injurious; hurtful. See examples of PERNICIOUS used in a sentence.

  6. Pernicious means harmful and subtle, such as a poison gas that causes illness in those exposed to it over the course of years.

  7. Definition of pernicious adjective in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.

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