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Robert Ironside (Raymond Burr), chief of detectives for the San Francisco Police Department, is vacationing when he is shot in an attempted murder. Although Ironside survives, the spinal damage leaves him paralyzed below the waist and wheelchair-bound. Though he must retire from the force, Ironside is determined to keep investigating crimes with assistants Ed Brown (Don Galloway), Mark Sanger (Don Mitchell) and Eve Whitfield (Barbara Anderson) -- starting by finding the man who shot him.