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- Season 6 overviewSep 24, 2009-May 20, 201024 episodesSeason 6 episodes24. Death and All His Friends May 20, 2010
- The hospital is hit with an unprecedented crisis; Meredith and Cristina's skills are tested.
- 23. Sanctuary; Death and All His Friends May 20, 2010
- The hospital is hit with an unprecedented crisis; Meredith and Cristina's skills are tested.
- 22. Shiny Happy People May 13, 2010
- Karev treats a troubled teen; Meredith shares her suspicions with Cristina.
- 21. How Insensitive May 6, 2010
- Bailey requires the team to have sensitivity training before admitting a 700-pound patient.
- 20. Hook, Line and Sinner Apr 29, 2010
- The doctors treat a crab boat captain who was stabbed with a giant shark hook.
- 19. Sympathy for the Parents Apr 1, 2010
- When Alex's brother shows up with a hernia, Alex must get approval for pro-bono surgery.
- 18. Suicide Is Painless Mar 25, 2010
- A patient's desire to end her life triggers haunting memories for Hunt.
- 17. Push Mar 11, 2010
- Owen and Richard compete for a difficult surgery; Bailey gets ready for another date with Ben.
- 16. Perfect Little Accident Mar 4, 2010
- A famous surgeon is rushed to the hospital; Callie and Arizona try to help Teddy and Sloan move on.
- 15. The Time Warp Feb 18, 2010
- Callie, Bailey and Richard present pivotal past cases when the hospital lecture series is restored.
- 14. Valentine's Day Massacre Feb 11, 2010
- The doctors treat dozens of people when the roof of a restaurant collapses on Valentine's Day.
- 13. State of Love and Trust Feb 4, 2010
- Derek faces a lawsuit on his first day as interim chief; Mark refuses to speak to Lexie.
- 12. I Like You So Much Better When You're Naked Jan 21, 2010
- After learning about Richard's drinking problem, Derek confronts him; Izzie returns.
- 11. Blink Jan 14, 2010
- Addison returns to Seattle to perform a procedure on Mark's pregnant daughter.
- 10. Holidaze Nov 19, 2009
- As the holiday season passes, Miranda is visited by her father, who disapproves of her life choices.
- 9. New History Nov 12, 2009
- Owen recruits a fellow Iraq War veteran to be the new cardiothoracic surgeon.
- 8. Invest in Love Nov 5, 2009
- Arizona has a conflict of interest when her patient's parents offer a generous donation.
- 7. Give Peace a Chance Oct 29, 2009
- A hospital lab tech learns he has an inoperable tumor wrapped around his spine.
- 6. I Saw What I Saw Oct 22, 2009
- When a burn victim unexpectedly dies in the ER, the residents must defend their actions.
- 5. Invasion Oct 15, 2009
- The residents of Seattle Grace and Mercy West vie for their careers as the hospital merger begins.
- 4. Tainted Obligation Oct 8, 2009
- When Thatcher returns to the hospital with a failed liver, Meredith must save his life.
- 3. (I Always Feel Like) Somebody's Watchin' Me Oct 1, 2009
- Izzie returns to work; Seattle Grace residents position themselves to avoid layoffs.
- 2. Goodbye Sep 24, 2009
- Members of the hospital staff find unique ways to deal with their grief at George's death.
- 1. Good Mourning Sep 24, 2009
- Members of the hospital staff find unique ways to deal with their grief at George's death.