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- Season 4 overviewSep 27, 2007-May 22, 200817 episodesSeason 4 episodes17. Freedom May 22, 2008
- Meredith and Derek get one last shot at success in their clinical trial.
- 16. Freedom May 22, 2008
- Meredith and Derek get one last shot at success in their clinical trial.
- 15. Losing My Mind May 15, 2008
- Dr. Wyatt won't let Meredith give up on therapy; Alex learns the truth about Rebecca's condition.
- 14. The Becoming May 8, 2008
- The nurses' complaints about Sloan's trysts result in a date-and-tell policy.
- 13. Piece of My Heart May 1, 2008
- Addison returns to Seattle Grace; Rebecca has shocking news for Alex.
- 12. Where the Wild Things Are Apr 24, 2008
- Meredith, Alex, Izzie and Cristina compete in a surgical contest, with Bailey serving as judge.
- 11. Lay Your Hands on Me Jan 10, 2008
- Bailey's family faces a medical trauma as her marriage falls apart; George's mother makes a visit.
- 10. Crash Into Me Dec 6, 2007
- Meredith furiously works to save the life of a paramedic trapped in an ambulance.
- 9. Crash Into Me Nov 22, 2007
- An ambulance crash endangers the lives of the paramedics involved.
- 8. Forever Young Nov 15, 2007
- Teenagers fill the ER after a school-bus crash; Derek goes on a date with a fellow doctor.
- 7. Physical Attraction ... Chemical Reaction Nov 8, 2007
- George and Izzie's romantic chemistry; Derek asks for more than a physical connection with Meredith.
- 6. Kung Fu Fighting Nov 1, 2007
- The chief has a gentlemen's evening with his fellow surgeons.
- 5. Haunt You Every Day Oct 25, 2007
- Halloween is full of surprises for the doctors of Seattle Grace.
- 4. The Heart of the Matter Oct 18, 2007
- The chief's wife rushes their niece to Seattle Grace; Izzie reveals her feelings about George.
- 3. Let the Truth Sting Oct 11, 2007
- George's skill dazzles the new interns; Meredith halfheartedly helps Lexie.
- 2. Love/Addiction Oct 4, 2007
- The residents and interns treat the victims of a massive explosion at an apartment building.
- 1. A Change Is Gonna Come Sep 27, 2007
- Meredith, Cristina, Izzie and Alex spend their first day as residents.
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