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What is protein phosphorylation?
How is protein phosphorylation regulated?
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How does phosphorylation affect a protein?
Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group.
Phosphoproteomics is a branch of proteomics that identifies, catalogs, and characterizes proteins containing a phosphate group as a posttranslational modification. Phosphorylation is a key reversible modification that regulates protein function, subcellular localization, complex formation, degradation of proteins and therefore cell signaling ...
May 1, 2002 · Phosphorylation and dephosphorylation, catalysed by protein kinases and protein phosphatases, can modify the function of a protein in almost every conceivable way; for example by increasing or...
- Philip Cohen
- 2002
Jun 22, 2017 · Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases.
- Fatima Ardito, Michele Giuliani, Donatella Perrone, Giuseppe Troiano, Lorenzo Lo Muzio
- 10.3892/ijmm.2017.3036
- 2017
- Int J Mol Med. 2017 Aug; 40(2): 271-280.
Apr 25, 2024 · Here we report a tailored workflow to detect and reliably assign protein pyrophosphorylation in two human cell lines, providing, to our knowledge, the first direct evidence of endogenous...
Sep 13, 2021 · Phosphorylation is a rapid and reversible kinetic enzymatic reaction that regulates protein activity and cellular processes via the attachment and detachment of a dianionic phosphate group on the residue of a protein, providing a change in the structural properties of proteins and regulation of protein–protein interactions.
