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Spike (S) glycoprotein (sometimes also called spike protein, [2] formerly known as E2 [3]) is the largest of the four major structural proteins found in coronaviruses. [4] The spike protein assembles into trimers that form large structures, called spikes or peplomers, [3] that project from the surface of the virion.
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2.The first known case was identified in Wuhan, China, in December 2019. Most scientists believe the SARS-CoV-2 virus entered into human populations through natural zoonosis, similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history.
Jun 14, 2021 · The spike protein (S) of SARS‐CoV‐2 is a trimeric class I fusion protein containing two subunits: S1 and S2, which remain noncovalently bound in a pre‐fusion metastable conformation 23, 24 protruding from the viral surface as a complete homotrimer and forming the distinctive surface spikes of coronaviruses. 25 The S protein of SARS‐CoV ...
- Chaogeng Zhu, Guiyun He, Qinqin Yin, Lin Zeng, Xiangli Ye, Yongzhong Shi, Wei Xu
- 10.1002/jmv.27132
- 2021
- J Med Virol. 2021 Oct; 93(10): 5729-5741.
Spike (S) glycoprotein is the largest of the four major structural proteins found in coronaviruses. The spike protein assembles into trimers that form large structures, called spikes or peplomers, that project from the surface of the virion. The distinctive appearance of these spikes when visualized using negative stain transmission electron microscopy, "recalling the solar corona", gives the ...
Aug 3, 2020 · It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell ...
Oct 5, 2021 · Together with Shang, J. et al., this study provides one of two early crystal structures of the SARS-CoV-2 RBD–ACE2 complex, revealing how the S protein recognizes its receptor. CAS PubMed Google ...
