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Porins are beta barrel proteins that cross a cellular membrane and act as a pore, through which molecules can diffuse. [1] . Unlike other membrane transport proteins, porins are large enough to allow passive diffusion, i.e., they act as channels that are specific to different types of molecules.
16.12: Structure of Porins. Mitochondria, chloroplasts, and gram-negative bacteria have transmembrane, beta-barrel proteins called porins to mediate the free diffusion of ions and metabolites across the membrane. Mitochondrial porin precursors contain conserved amino acid sequences called beta signals at their C-terminal.
Porins, hydrophilic transmembrane channel proteins, are one of the most abundant proteins in the outer membrane of gram-negative bacteria (Fig. 1).
This review evaluates the impact of porins and efflux pumps on two major types of resistance, namely, mutational and adaptive types of resistance, both of which are regarded as key phenomena in the global rise of antibiotic resistance among pathogenic microorganisms.
212 Citations. 30 Altmetric. Metrics. Abstract. Gram-negative bacteria and their complex cell envelope, which comprises an outer membrane and an inner membrane, are an important and attractive...
Porins are proteins that are located in the outer membrane of Gram-negative bacteria . They function to form a water-filled pore through the membrane, from the exterior to the periplasm , which is a region located between the outer and inner membranes.
Porins. Outer membrane proteins. Outer membrane protein biogenesis. Porin regulation. Envelope permeability. Protein channels. Antibiotic resistance. Introduction. Antibacterial drug resistance is broadly recognized as a growing threat to human health (O’Neill 2016; WHO 2014; NIAID 2014 ).
