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Feb 24, 2022 · A treatment plan for bipolar disorder might include mood stabilizers and atypical antipsychotics in addition to therapy and self-care or lifestyle changes.. In the past, doctors and psychiatrists ...
May 11, 2021 · To be included in this NMA, studies must have been double-blinded randomized controlled trials (RCTs) of adults (≥18 years old), with either bipolar I disorder or bipolar II disorder (at least 50% with bipolar I disorder), treated with an atypical antipsychotic as monotherapy, and reported at least one outcome of interest at study endpoint of ...
- Aditi Kadakia, Carole Dembek, Vincent Heller, Rajpal Singh, Jennifer Uyei, Katsuhiko Hagi, Tadashi N...
- 10.1186/s12888-021-03220-3
- 2021
- BMC Psychiatry. 2021; 21: 249.
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Jan 3, 2020 · The Table provides dosage ranges for the four atypical antipsychotics that are FDA-approved for bipolar depression. Most of the other atypical antipsychotics have been tried but failed to show efficacy in bipolar depression, including a few that work in unipolar depression: aripiprazole, ziprasidone, and risperidone. 2 Asenapine (Saphris ...
- Chris Aiken, MD
- Literature Review Update
- Study Characteristics
- Efficacy Measures
- Discontinuation Rates
- Metabolic Parameters Measures
- Other Tolerability Measures
- Nnt/Nnh
- Sensitivity Analyses
- Quality of Evidence and Heterogeneity
The update to the systematic literature review identified 1791 records in EMBASE, MEDLINE, the Cochrane Library, and PsycINFO for screening (Fig. 1). A total of 111 full-text articles and secondary conference abstracts were reviewed with 17 records meeting all the inclusion criteria. In addition, 6 more records were identified from searches of the ...
All studies were multi-site, randomized, double-blind, and placebo-controlled clinical trials. There were no head-to-head trials of atypical antipsychotics. Most trials were multi-national, but eight recruited only from sites in the United States (US) [35, 37, 39, 41,42,43] and two recruited only from sites in the People’s Republic of China [36, 46...
Lurasidone, olanzapine, quetiapine, and cariprazine (but not aripiprazole or ziprasidone) were all significantly more efficacious than placebo in change from baseline in MADRS but there was a larger magnitude of change for lurasidone, quetiapine and olanzapine versus placebo (Table 3). According to SUCRA rankings, lurasidone, olanzapine and quetiap...
All-cause discontinuation for lurasidone, olanzapine, cariprazine and, ziprasidone, were comparable to placebo. However, the odds of all-cause discontinuation for aripiprazole were significantly higher than placebo (Table 6). Based on SUCRA ranking, olanzapine and quetiapine ranked the best tolerated treatments in terms of all-cause discontinuation...
All atypical antipsychotics except lurasidone and aripiprazole were associated with significantly more weight gain than placebo. During the short-term trials, olanzapine had the largest mean weight gain relative to placebo (2.88 kg), followed by quetiapine (1.17 kg), cariprazine (0.65 kg), lurasidone (0.34 kg), and aripiprazole (0.20 kg). Olanzapin...
Lurasidone was associated with higher changes in prolactin than placebo, aripiprazole, and quetiapine; and cariprazine was also associated with higher changes in prolactin than placebo (Table 11). According to SUCRA ranking for changes in prolactin aripiprazole ranked first followed by quetiapine, cariprazine and lurasidone (Table 14). All antipsyc...
Descriptive estimates of the number needed to treat (NNT) to achieve one additional responder relative to placebo and the number needed to harm (NNH) based on one additional all-cause discontinuation and discontinuation due to adverse events relative to placebo were calculated for each treatment arm. Lurasidone (5) had the lowest NNT value for resp...
Dose stratified sensitivity analysis results were largely similar to the base case findings. For cariprazine, only the 1.5 mg and 3.0 mg cariprazine treatment arms used once daily were significantly greater than placebo, whereas all the stratified doses for lurasidone, olanzapine, and quetiapine were significantly more efficacious than placebo.
Overall, the quality of evidence for the primary outcome was high for direct evidence with quality reduced for NMA evidence, primarily because of indirectness of results and imprecisions. For all other outcomes, in general, lurasidone vs placebo and cariprazine vs placebo comparisons had higher quality, whereas ziprasidone vs placebo, and aripipraz...
- Aditi Kadakia, Carole Dembek, Vincent Heller, Rajpal Singh, Jennifer Uyei, Katsuhiko Hagi, Tadashi N...
- 2021
Jun 9, 2020 · Several atypical antipsychotics have been investigated for the treatment of bipolar depression, but quetiapine is currently the only antipsychotic to be approved for this condition in Europe. 44 In the USA, the Food and Drug Administration has approved olanzapine–fluoxetine combination therapy for the treatment of depressive episodes ...
- Nefize Yalin, Allan H Young
- 10.2147/NDT.S245166
- 2020
- 2020
Similarly, long-term studies are needed to ascertain the role of risperidone, quetiapine, and ziprasidone in the maintenance treatment of bipolar disorder. Overall, the atypical antipsychotic agents as a group represent an effective and relatively safe addition to the armamentarium for the treatment of bipolar disorder.
Nov 11, 2020 · We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the ...
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