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1. en.wikipedia.org › wiki › Immunoreceptor_tyrosineImmunoreceptor tyrosine-based inhibitory motif - Wikipedia

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   An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells.

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   What is the structure of ITIM?

   • ITIMs have similar structures of S/I/V/LxYxxI/V/L, where x is any amino acid, Y is a tyrosine residue that can be phosphorylated, S is the amino acid serine, I is the amino acid isoleucine, and V is the amino acid valine. [ 3] ITIMs recruit SH2 domain -containing phosphatases, which inhibit cellular activation.

   Immunoreceptor tyrosine-based inhibitory motif - Wikipedia

   en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_inhibitory_motif

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   What are ITIM motifs?

   • [ 6] ITIM motifs are defined as six amino acid signature with the consensus sequence S/I/V/LxYxxL/V, where x stands for any amino acid, Y for a tyrosine residue that can be phosphorylated and S, I, V for amino acids serine, isoleucine, and valine, respectively. [ 2]

   Immunoreceptor tyrosine-based inhibitory motif - Wikipedia

   en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_inhibitory_motif

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   What is the role of ITIM bearing receptors in the immune system?

   • ITIM bearing receptors have important role in regulation of immune system allowing negative regulation at different levels of the immune response. [ 4] A list of human candidate ITIM-containing proteins has been generated by proteome-wide scans. [ 5] It has included more than 135 proteins with ITIM motif.

   Immunoreceptor tyrosine-based inhibitory motif - Wikipedia

   en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_inhibitory_motif

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   What is ITIM tyrosine based switch motif?

   • Professional illustration by Patrick Lane, ScEYEnce Studios. A third ITIM-like motif, termed an immunoreceptor tyrosine–based switch motif (ITSM, consensus sequence TxYxxV/I), 11 was subsequently described that confers activating and/or inhibitory properties to a receptor, depending on the associated signaling proteins.

   ITIM receptors: more than just inhibitors of platelet activation

   ashpublications.org/blood/article/129/26/3407/36232/ITIM-receptors-more-than-just-inhibitors-of

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3. www.ncbi.nlm.nih.gov › pmc › articlesITAMs versus ITIMs: striking a balance during cell regulation

   www.ncbi.nlm.nih.gov › pmc › articles

   Jan 1, 2002 · ITIMs. There is an increasing recognition that the attenuation or termination of many immune responses is not simply due to the loss of activating signals. The emerging paradigm focuses on how the balance between positive and negative signals determines functional outcomes ( 4, 34 ).

   • Author: Daniel D. Billadeau, Paul J. Leibson
   • DOI: 10.1172/JCI14843

   • Publish Year: 2002
   • Publication: J Clin Invest. 2002 Jan 15; 109(2): 161-168.

4. www.nature.com › articles › nriITIMs: episode 1 of the inhibitory saga | Nature Reviews ...

   www.nature.com › articles › nri

   Nov 27, 2017 · The authors coined the term ITIM (immunoreceptor tyrosine-based inhibition motif) to describe this inhibitory intracellular signalling domain.

   • Author: Eric Vivier
   • Email: vivier@ciml.univ-mrs.fr

   • Publish Year: 2018

5. www.tagalog.com › dictionary › itimItim in English: Definition of the Tagalog word itim

   www.tagalog.com › dictionary › itim

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   Definition of the Tagalog word itim in English with 6 example sentences, and audio.

6. www.wordhippo.com › what-is › the-meaning-ofWhat does itim mean in Filipino? - WordHippo

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   What does itim mean in Filipino? itim. English Translation. black. More meanings for itim. black noun. madilim, malungkot, labag sa batas. ebony adjective.

7. ashpublications.org › blood › articleITIM receptors: more than just inhibitors of platelet activation

   ashpublications.org › blood › article

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   Jun 29, 2017 · Since their discovery, immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptors have been shown to inhibit signaling from immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors in almost all hematopoietic cells, including platelets.

8. www.acronymfinder.com › ITIMITIM - Definition by AcronymFinder

   www.acronymfinder.com › ITIM

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   10 definitions of ITIM. Meaning of ITIM. What does ITIM stand for? ITIM abbreviation. Define ITIM at AcronymFinder.com