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Karl Theodor Fahr ( German pronunciation: [kaʁl ˈteːodoːɐ̯ ˈfaːɐ̯]; 3 October 1877 – 29 October 1945) was a German pathologist born in Pirmasens of the Rhineland-Palatinate . In 1903 he earned his medical doctorate from the University of Giessen, afterwards continuing his studies with Eugen Bostroem (1850-1926) in Giessen, under ...
Sep 15, 2017 · In 1930, a German pathologist, Karl Theodor Fahr, described a case of a man with symmetrical calcifications of the basal ganglia and cerebral cortex . The syndrome, named after this author, manifests with a wide range of neurological as well as psychiatric symptoms.
- Krzysztof Jaworski, Maria Styczyńska, Monika Mandecka, Jerzy Walecki, Dariusz A. Kosior
- 10.12659/PJR.902024
- 2017
- Pol J Radiol. 2017; 82: 490-493.
Oct 8, 2013 · It was first described by German neurologist Karl Theodor Fahr in 1930 .It is characterized by abnormal deposition of calcium in areas of the brain that control movements including basal ganglia, thalamus, dentate nucleus, cerebral cortex, cerebellum, subcortical white matter, and hippocampus .Most cases present with extra pyramidal symptoms ...
- Shafaq Saleem, Hafiz Muhammad Aslam, Maheen Anwar, Shahzad Anwar, Maria Saleem, Anum Saleem, Muhamma...
- 2013
- Terminology
- Epidemiology
- Clinical Presentation
- Pathology
- Radiographic Features
- Treatment and Prognosis
- Differential Diagnosis
There is confusion in the literature as to whether Fahr disease and Fahr syndromeare synonymous or not. Generally, the terms are used interchangeably, further divided into: 1. primary: equivalent to familial cerebral ferrocalcinosis or primary familial brain calcification(now the preferred term), with no underlying other cause, and 2. secondary: du...
Calcification of basal ganglia is very common, and age dependent, with small amounts of calcification confined to the globus pallidus, considered a "normal" finding in the elderly. Symptomatic onset for primary familial brain calcification (Fahr disease) tends to be between age 40 and 60 years 5. Incidence is unknown.
The clinical presentation is variable, with many individuals remaining asymptomatic. Severe forms can later present with parkinsonism, other movement disorders (e.g. chorea, dystonia), headache, seizures and epilepsy, psychosis, depression, and progressive cognitive impairment 6,9.
Fahr disease is characterized by deposition of calcium in the walls of the capillaries and larger arteries and veins. Other compounds, such as mucopolysaccharides, and elements, including magnesium, zinc, aluminum, and iron, have also been found deposited in the vessels. Calcification can be found in the globus pallidus, putamen, caudate, thalamus,...
Calcification is extensive and has a relatively typical distribution 3: 1. basal ganglia and thalami 1.1. symmetric involvement of caudate, lentiform nucleus, thalamus, and dentate nuclei 1.2. globus pallidus affected first 2. subcortical white matter The MRI appearance varies depending on the degree of calcification and the stage of the disease an...
Primary familial brain calcification (Fahr disease) progresses steadily, and there currently is no known cure or specific treatment, thus management is supportive depending on the clinical manifestations. There is a correlation between the extent of brain calcification and the symptom severity 11. In Fahr syndrome, treatment should be aimed at the ...
The differential for primary familial brain calcification (Fahr disease) is that of Fahr syndrome (see above). Also, refer to the article basal ganglia calcification.
Aug 13, 2023 · Fahr disease is named after Karl Theodor Fahr, a German neurologist who first reported the disorder in 1930. It is a rare neurological condition characterized by abnormal idiopathic calcification of basal ganglia and commonly has an autosomal dominant inheritance.
- Fnu Amisha, Sunil Munakomi
- 2023/08/13
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Why is Fahr disease called Fahr disease?
What is Fahr syndrome?
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Aug 13, 2023 · Fahr disease is named after Karl Theodor Fahr, a German neurologist who first reported the disorder in 1930. It is a rare neurological condition characterized by abnormal idiopathic calcification of basal ganglia and commonly has an autosomal dominant inheritance.
Aug 1, 2021 · Theodor Fahr was a German pathologist who gained international fame for his work on renal, vascular and neuropathology [ 1 ]. He is best known for the discovery of the eponymous “Fahr’s disease”, which is also known today as primary familial cerebral calcification or familial idiopathic basal ganglia calcification.
