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Svante Paabo. Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. TD Kocher, WK Thomas, A Meyer, SV Edwards, S Pääbo, FX Villablanca, ... RE...
Dec 29, 2022 · Svante Pääbo, a Swedish geneticist who directs the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, was awarded the 2022 Nobel Prize in Physiology or Medicine for pioneering the extraction and analysis of DNA from ancient bones, above all those of the Neanderthals.
Oct 3, 2022 · 03 October 2022. Correction 04 October 2022. Geneticist who unmasked lives of ancient humans wins medicine Nobel. Svante Pääbo has made stunning discoveries about human evolution using ancient...
- How Did You End Up in The Pond?
- What Inspired You to Begin Looking at Genetic Material from Ancient Humans?
- What Accomplishment Are You Most Proud of?
- What Keeps You Motivated?
- What’s The Ultimate Goal of These Kinds of Study?
- What About Recreating Neanderthal Or Denisovan tissue?
It’s a tradition at our institute that you throw PhD candidates into the pond when they pass their exams. And some people had the idea that it would be appropriate to throw me into the pond. It was the second time, actually — there has been one crazy party before where that happened. But that’s a long time ago. I hope this is the last time I end up...
As a kid, I always wanted to be an archaeologist or Egyptologist. And then I started studying that at university. But I had much too romantic ideas about what it would be like. I ended up studying medicine and molecular biology. And then the thought was not that far away that techniques were coming along to clone DNA and study DNA sequences from li...
The one moment that was probably the most amazing was getting the first DNA sequences from the mitochondrial genome of a Neanderthal4. We knew the variation among present-day human mitochondria. So we immediately realized that it was very human-like — but not like any human living today. That was the first time we realized that it was indeed a DNA ...
I’m really focusing on the genetic changes that distinguish modern humans from Neanderthals. There was this recent paper we published in Science on a uniquely human mutation that makes more neurons during brain development when we put this change into a mouse or ferret7.
We’ll probably never be able to fully understand what went on in the past, of course, but we might be able to understand some important aspects of it. I do think that there is something special about human sociality and modern human cognition, that we might be able to understand aspects of.
To do that fully is probably beyond my lifetime in science. But one could dream about making all the changes in amino acids back to the ancestral state, for example. To do that would require making on the order of 100 changes in the genome. That is on the horizon of technology.
- Ewen Callaway
1. S. Pääbo, Neanderthal Man: In Search of Lost Genomes (Basic Books, New York, NY, 2014), p. 287. Google Scholar. 2. S. Pääbo, Molecular cloning of Ancient Egyptian mummy DNA. Nature 314, 644–645 (1985). Crossref. PubMed. Google Scholar. 3. J. Gitschier, Imagine: An Interview with Svante Pääbo. PLoS Genet. 4, e1000035 (2008). Crossref. PubMed.
As of October 2022, Pääbo has an h-index of 167 according to Google Scholar and of 133 according to Scopus. Awards and honours Pääbo showed the medal of Nobel Prize in Physiology or Medicine to Fumio Kishida (February 1, 2023).
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Nov 23, 2022 · Path of Svante Pääbo's research career and the development of paleogenetics: from extracting short fragments of mtDNA from an Egyptian mummy to sequencing whole genomes of extinct hominids and discerning the evolutionary history of their and our species, for which he was awarded the Noble Prize.
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