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Dec 6, 2019 · Review preoperative risk assessment strategies to guide hemostatic cover at the time of surgery for people with von Willebrand disease. Understand the distinctions between differing von Willebrand factor replacement therapies and the timing of administration preoperatively
- James S. O’Donnell, Michelle Lavin
- 2019
Oct 26, 2021 · Many doctors consider desmopressin (DDAVP) the first treatment for managing von Willebrand disease. It can be used before minor surgical procedures to help control bleeding. You might be given a trial of desmopressin to make sure it's effective for you.
Jan 1, 2022 · Treatment options for patients with VWD who are undergoing surgery include administration of VWF-containing concentrates (both plasma derived and recombinant), desmopressin to induce release of stored endogenous VWF from the vascular endothelium, and adjunctive antifibrinolytic therapy such as tranexamic acid (TXA). 4.
- 10.1182/bloodadvances.2021005666
- 2022/01/01
- Blood Adv. 2022 Jan 11; 6(1): 121-128.
Jun 4, 2020 · Loading doses: VWF 50-60 IU/kg 12-24 h before surgery if FVIII levels <60 IU/dL, and VWF 50-60 IU/kg 1 h before surgery (in unscheduled procedures a single loading dose 1 h before surgery together with a dose of FVIII to obtain FVIII levels >60 IU/dL)
- Wolfgang Miesbach
- 2020
Jan 12, 2021 · Major therapies include use of desmopressin to induce endothelial release of stored von Willebrand factor (VWF) and factor VIII (FVIII) and use of VWF concentrates, including both plasma-derived and recombinant products, as well as adjuvant therapies, such as antifibrinolytic tranexamic acid.
- Nathan T. Connell, Veronica H. Flood, Romina Brignardello-Petersen, Rezan Abdul-Kadir, Alice Arapshi...
- 2021
Apr 16, 2024 · Treatment of severe bleeding — If you are in an accident or have severe bleeding with surgery despite receiving the treatments above, you may be given additional von Willebrand factor, other medications, and/or platelet transfusions. It may be necessary to receive treatment for several days when severe bleeding occurs.
Aug 30, 2021 · Von Willebrand disease is a hereditary disease associated with a tendency to bleed, and it is important to reduce the possibility of bleeding in a procedure. This case describes the use of a hemostatic factor, Factor VIII concentrate (Confact F ® ), during a dental procedure involving teeth extraction and implant placement.
