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What is affinity maturation in immunology?
What is affinity maturation?
What is the difference between somatic hypermutation and affinity maturation?
What is in vitro affinity maturation?
In immunology, affinity maturation is the process by which T FH cell -activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities.
Affinity maturation is the process by which antibodies gain increased affinity, avidity, and anti-pathogen activity and is the result of somatic hypermutation (SHM) of immunoglobulin genes in B cells, coupled to selection for antigen binding (Figure 1).
- Nicole A Doria-Rose, M Gordon Joyce
- 10.1016/j.coviro.2015.04.002
- 2015
- 2015/04
Affinity maturation is the process by which B cells increase their affinity for a particular antigen. This "fine tuning" of B-cell specificity occurs through a repeated process of somatic hypermutation of B-cell receptors and subsequent clonal selection.
Feb 1, 2018 · Affinity maturation is the process whereby the immune system generates antibodies of higher affinities during a response to antigen. It is unique in being the only evolutionary mechanism known to operate on a molecule in an organism’s own body.
- Arjun K Mishra, Roy A Mariuzza
- 10.3389/fimmu.2018.00117
- 2018
- Front Immunol. 2018; 9: 117.
Nov 12, 2021 · Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to fulfil the therapeutic potential of antibodies.
- Denice T.Y. Chan, Maria A.T. Groves
- 2021/11/11
- 10.1042/ETLS20200331
Somatic hypermutation and affinity maturation are two mechanisms by which the immune system can adapt to better recognize and neutralize pathogens.
Feb 18, 2016 · This phenomenon is known as affinity maturation and is the result of a Darwinian process that alternates stochastic somatic hypermutation (SHM) of immunoglobulin (Ig) genes with the selection and clonal expansion of B cells that have acquired affinity-enhancing mutations ( 2 ).
