Search results
Jul 15, 2019 · Erythema multiforme is caused by a cell-mediated immune response, and infections are associated with 90% of cases. 6 Although herpes simplex virus (HSV) type 1 is the most commonly identified ...
A 61-year-old African American female presented with a 1-year history of an asymptomatic bump on her right thumb that had been gradually increasing in size. Examination revealed a firm, well-circumscribed, smooth, pale white nodule with peripheral erythema on the ventral aspect of the right thumb just proximal to the interphalangeal joint (Fig ...
Oct 21, 2022 · The treatment of urticaria multiforme with oral antihistamines is largely for symptom management given the rash will self-resolve in 2-10 days. Administering the first dose of antihistamine while in the emergency department, and watching for improvement in the rash’s appearance, can help to definitively make this diagnosis. CASE RESOLUTION.
- What Is Erythema Multiforme?
- Who Gets Erythema Multiforme?
- What Causes Erythema Multiforme?
- What Are The Clinical Features of Erythema Multiforme?
- How Do Clinical Features Vary in Differing Types of Skin?
- What Are The Complications of Erythema Multiforme?
- How Is Erythema Multiforme Diagnosed?
- What Is The Differential Diagnosis For Erythema Multiforme?
- What Is The Treatment For Erythema Multiforme?
- What Is The Outcome For Erythema Multiforme?
Erythema multiforme is an immune-mediated, typically self-limiting, mucocutaneous condition characterised by ‘target’ lesions. Significant mucosal involvement distinguishes erythema multiforme major from multiforme minor. Episodes can be isolated, recurrent, or persistent. In most cases, erythema multiforme is precipitated by herpes simplex virus (...
Erythema multiforme affects less than 1% of the population. It is most common in young adults (aged 20–40 years) with a modest predominance in males. There is no association with race. There appears to be a genetic predisposition in people carrying the HLA-DQB1*0301 allele, which shares an even stronger association with herpes-related erythema mult...
Infection precipitates 90% of cases, with HSV type 1 being the predominant cause. Other infectious triggers include: 1. HSV type 2 2. Cytomegalovirus 3. Epstein-Barr virus 4. Influenza virus 5. Vulvovaginalcandidiasis 6. SARS-CoV-2 7. Orf. Mycoplasma pneumoniae infection is often listed as a trigger of erythema multiforme, however mucocutaneous man...
Many patients report prodromal symptoms including fatigue, malaise, myalgia, or fever. These likely represent the course of precipitating illness rather than true prodrome.
No documented variation across skin type.No known associations with race.Cutaneous lesions resolve without scarring, though hyperpigmentation may persistfor several months. Ocular involvement can lead to more serious complications including: 1. Keratitis 2. Conjunctival scarring 3. Uveitis 4. Permanent visual impairment.
Diagnosis is often made based on history and clinical examination. Where there is doubt about the diagnosis, consider: 1. Complete blood examination 2. Liver functions tests 3. ESR 4. Serologicaltesting for infectious causes 5. Chest x-ray. Skin biopsy with histopathology and direct immunofluorescence can be non-specific but helps to distinguish er...
Viral exanthemFixed drug eruptionTreatment is often not needed as episodes are typically self-limiting with no ongoing complications. However, ocular involvement should always prompt ophthalmology referral given the risk for more serious sequelae. Treatment of symptomatic mild cases: 1. Itch — oral antihistamines and/or topical steroidsfor itch or discomfort associated with cutane...
Erythema multiforme is self-limiting with little to no ongoing complication in most patients. Recurrent or persistent disease comes with additional treatment challenges, but remission can be achieved.
Jul 15, 2020 · I needed to search my Atlas of African Dermatology to find that one presentation of erythema multiforme was target lesions composed of different shades of brown. 1 This information gap highlights ...
Oct 26, 2023 · Erythema migrans. Outlook. Erythema multiforme is an immune-mediated reaction that causes a raised, red, target-like rash on the skin or mucous membranes. It often resolves on its own but may ...
People also ask
Is erythema multiforme related to race?
What does erythema multiforme look like?
When does erythema multiforme develop?
Jan 1, 1990 · Erythema multiforme is a distinctive hypersensitivity syndrome characterized by skin and mucous membrane lesions and, in its more severe forms, mucosal lesions with constitutional symptoms and, at times, visceral involvement.1,2 It is usually considered acute and self-limiting, but recent observations indicate that it may also behave as a chronic recurrent disorder in many people.1,3,4 The ...
