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- Sir Ernst Boris Chain was a German-born British biochemist who, with pathologist Howard Walter Florey, isolated and purified penicillin (which had been discovered in 1928 by Sir Alexander Fleming) and performed the first clinical trials of the antibiotic.
www.britannica.com › biography › Ernst-Boris-ChainSir Ernst Boris Chain | Nobel Prize, Penicillin & Antibiotic ...
Howard Walter Florey (1898–1968) and Ernst Boris Chain (1906–1979) were the scientists who followed up most successfully on Alexander Fleming’s discovery of penicillin, sharing with him the 1945 Nobel Prize in Physiology or Medicine.
Florey and Chain developed a system of growing penicillin: which was complicated initially, and tested its effectiveness on mice. The tests were successful and the two men became convinced that the drug would cure many people who would otherwise die.
Mar 29, 2017 · Norman Heatley, a young chemist in Florey’s lab, played a key role in the process of penicillin purification. Heatley and Chain designed early methods for extracting penicillin, which was needed to obtain enough material to perform the first trials with the drug.
- Mariya Lobanovska, Giulia Pilla
- Yale J Biol Med. 2017 Mar; 90(1): 135-145.
- 2017
- 2017/03
Howard Walter Florey, Baron Florey (born Sept. 24, 1898, Adelaide, Australia—died Feb. 21, 1968, Oxford, Eng.) was an Australian pathologist who, with Ernst Boris Chain, isolated and purified penicillin (discovered in 1928 by Sir Alexander Fleming) for general clinical use.
- The Editors of Encyclopaedia Britannica
The Nobel Prize in Physiology or Medicine 1945 was awarded jointly to Sir Alexander Fleming, Ernst Boris Chain and Sir Howard Walter Florey "for the discovery of penicillin and its curative effect in various infectious diseases".
At Florey’s suggestion, Chain began studying lysozyme and in 1938 became aware of Fleming’s work on penicillin. After reproducing Duchesne's experiments in animals, Florey and Chain began making penicillin in porcelain vessels.
Ernst Boris Chain, a German-born biochemist, shared the 1945 Nobel Prize in medicine or physiology with pathologist Howard W. Florey (1898–1968) and bacteriologist Alexander Fleming (1881–1955) “for the discovery of penicillin and its curative value in a number of infectious diseases.”
