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Jul 3, 2021 · The vaccine mRNA BNT-162b2 is publicly available [ 3 ]. The sequence of mRNA-1273 was taken from Jeong et al. [ 4 ], and should be considered putative. However, the 5′-UTR of this putative sequence is identical to one of the 5′-UTR sequences (SEQ ID NO 181) in a Moderna patent [ 18 ].
Aug 5, 2020 · Nature - mRNA-1273, an mRNA vaccine that encodes a stabilized prefusion-state severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, elicits robust...
- Kizzmekia S. Corbett, Darin K. Edwards, Sarah R. Leist, Olubukola M. Abiona, Seyhan Boyoglu-Barnum, ...
- 2020
A Known DNA (or RNA) Sequence Can Serve as the Basis for an mRNA Vaccine, Which is then Formulated with Lipid Nanoparticles (LNPs) Buffers. mRNA-1273 encodes for the full-length Spike Protein in the Pre-fusion Conformation (S-2P) mRNA-1273 Preclinical & Clinical Programs.
Jul 14, 2020 · The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein. Methods. We conducted a phase 1, dose-escalation, open-label trial including 45 healthy...
- Lisa A. Jackson, Evan J. Anderson, Nadine G. Rouphael, Paul C. Roberts, Mamodikoe Makhene, Rhea N. C...
- 2020
Dec 30, 2020 · The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local and systemic reactions, no safety concerns were identified.
- Lindsey R. Baden, Hana M El Sahly, Brandon J Essink, Karen Kotloff, Sharon Frey, Rick Novak, David D...
- 2021
Sep 20, 2023 · Steps for selection of the bivalent mRNA-1273 cohort (n = 290,292), the ≥2 monovalent mRNA vaccine cohort (n = 580,584), and the COVID-19 unvaccinated cohort (n = 204,655) by inclusion and ...
For adults aged 17 and above, SAGE recommends the use of the Moderna mRNA-1273 vaccine at a schedule of two doses (100 µg, 0.5 ml each) 8 weeks apart. For adolescents aged 12 to 17 years, SAGE recommends 2 doses (100 µg, 0.5 ml each), given intramuscularly, 4 weeks apart.
