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  1. Aug 8, 2023 · The vector for epidemic typhus is the human body louse. R. prowazekii multiplies in the gut epithelium of the body louse and explodes into the gastrointestinal (GI) tract, eventually killing the body

  2. Apr 22, 2024 · Rickettsia prowazekii. Rickettsia prowazekii is the agent that causes epidemic typhus, also known as louse-borne typhus, or louse-borne fever. Epidemic typhus is rare in the United States and often occurs in areas of widespread body louse infestations, overcrowding, and poor sanitary conditions (Durden 2019).

  3. Rickettsial pathogens are highly specialized for obligate intracellular survival in both the vertebrate host and the invertebrate vector. While studies often focus primarily on the vertebrate host, the arthropod vector is often more important in the natural maintenance of the pathogen.

  4. Jan 30, 2023 · 3516 Accesses. 6 Citations. 4 Altmetric. Metrics. Abstract. Background. The availability of molecular techniques has significantly increased our understanding of bacteria of the order Rickettsiales, allowing the identification of distinct species in both vector and host arthropods.

  5. The principal vector of R. prowazekii is the human body louse. Lice become infected when they feed on a person with circulating R. prowazekii in their blood. Infective rickettsiae invade cells that line the louse gut, and multiply there, eventually causing the cells to rupture.

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