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SAPHO syndrome is a rare disorder with a wide range of possible symptoms. Some common symptoms include blisters, acne, and inflammation of the joints and bones.
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SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones).
Jun 7, 2024 · The SAPHO syndrome was given its acronymic name based upon the presence of synovitis, acne, pustulosis, hyperostosis, and osteitis in the patients described in early reports. It is a rare inflammatory disorder of bone, joints, and skin, which was first described as a syndrome in 1987 [ 1,2 ].
Jul 14, 2023 · What are the symptoms of SAPHO syndrome? SAPHO syndrome causes inflammation of joints with pain, stiffness, swelling, warmth, and redness. Joints affected can be spinal or away from the spine (peripheral joints) such as the finge rs, wrists, or knees.
SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes. These diseases share some clinical, radiologic, and pathologic characteristics. An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972.
Jul 23, 2020 · Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role.
Dec 26, 2023 · The clinical syndrome including synovitis, acne, (palmoplantar) pustulosis and hyperostosis osteitis, also known as synovitis acne pustulosis hyperostosis osteitis (SAPHO), constitutes a rare systemic inflammatory disease of currently unknown aetiopathology. 1–4 SAPHO is characterised by osteoarticular and dermatological features following a ...
