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What is the pathophysiology of sepsis?
Do different types of bacteria affect the pathophysiology of sepsis?
How is sepsis diagnosed?
Jan 18, 2024 · Sepsis results when the response to infection becomes generalized and involves normal tissues remote from the site of injury or infection. The pathophysiology of sepsis and mechanisms of multiple organ system dysfunction are reviewed here. The definition and management of sepsis are discussed separately.
Mar 21, 2019 · Sepsis is a medical emergency that describes the body’s systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death.
- Bishal Gyawali, Karan Ramakrishna, Amit S Dhamoon
- 2019
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Symptoms of sepsis
Symptoms of sepsis may include:
Symptoms of septic shock
Sepsis may progress to septic shock. Septic shock is a severe drop in blood pressure. Progression to septic shock raises the risk of death. Symptoms of septic shock include:
Any infection could lead to sepsis. Go to a health care provider if you have symptoms of sepsis or an infection or wound that isn't getting better.
Symptoms such as confusion or fast breathing need emergency care.
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Any type of infection can lead to sepsis. This includes bacterial, viral or fungal infections. Those that more commonly cause sepsis include infections of:
•Lungs, such as pneumonia.
•Kidney, bladder and other parts of the urinary system.
•Digestive system.
•Bloodstream.
•Catheter sites.
Some factors that increase the risk infection will lead to sepsis include:
•People over age 65.
•Infancy.
•People with lower immune response, such as those being treated for cancer or people with human immunodeficiency virus (HIV).
•People with chronic diseases, such as diabetes, kidney disease or chronic obstructive pulmonary disease (COPD).
•Admission to intensive care unit or longer hospital stays.
As sepsis worsens, vital organs, such as the brain, heart and kidneys, don't get as much blood as they should. Sepsis may cause atypical blood clotting. The resulting small clots or burst blood vessels may damage or destroy tissues.
Most people recover from mild sepsis, but the mortality rate for septic shock is about 30% to 40%. Also, an episode of severe sepsis raises the risk for future infections.
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By Mayo Clinic Staff
Feb 10, 2023
1.Forrester JD. Sepsis and septic shock. Merck Manual Professional Version. https://www.merckmanuals.com/professional/critical-care-medicine/sepsis-and-septic-shock/sepsis-and-septic-shock. Accessed Nov. 19, 2022.
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May 14, 2021 · Abstract. Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology.
- Dominik Jarczak, Stefan Kluge, Axel Nierhaus
- 10.3389/fmed.2021.628302
- 2021
- Front Med (Lausanne). 2021; 8: 628302.
The pathophysiology of sepsis is complex and results from the effects of circulating bacterial products, mediated by cytokine release, caused by sustained bacteraemia. Cytokines are primarily responsible for the clinically observable effects of the bacteraemia in the host.
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Pathophysiology |. Symptoms and Signs |. Diagnosis |. Treatment |. Prognosis |. Key Points. Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection.
Sep 10, 2018 · Sepsis occurs when the body's immune system reacts systemically to an infection, causing injury to tissue and organs. It is a highly serious condition with the...
