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Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.
Most people with factor V Leiden never develop abnormal clots. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening.
Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendenc...
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The factor V Leiden mutation does not itself cause any symptoms. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot.
Some clots do no damage and disappear on their own. Others can be life-threatening. Symptoms of a blood clot depend on what part of your body is affected.
If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Inheriting one copy slightly increases your risk of developing blood clots. Inheriting two copies — one from each parent — significantly increases your risk of developing blood clots.
Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots.
However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. These precautions might include:...
For informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment.
© Mayo Clinic
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