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This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential ...
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol 91:2080–2090.
Jul 16, 2020 · Chronic hepatitis B (CHB) remains a major global health problem affecting more than 240 million people with high liver-related morbidity and mortality worldwide. This snapshot summarizes available HBV therapeutic strategies and highlights their corresponding stages of development from late preclinical to various clinical phases, which are indicated by different colors.
- Karim Mouzannar, T Jake Liang
- 2020
Ads · Hepatitis B research books
For correspondence: s.nayagam01@imperial.ac.uk. 1. Background. Hepatitis B virus (HBV) infection is highly prevalent worldwide, with a disproportionately high burden in low- and middle-income countries (LMICs). 1 There is mounting evidence regarding the efficacy of antiviral therapy in the reduction of disease progression to cirrhosis and hepatocellular carcinoma (HCC).
Apr 8, 2024 · Research Highlights 22 May 2024 Nature Reviews Gastroenterology & Hepatology. P: 1. ... Vaccination is a key intervention for the elimination of hepatitis B virus (HBV) and hepatitis C virus (HCV ...
May 1, 2021 · Eight NAs have been approved against the HBV, of which the current recommended ones are entecavir and the two tenofovir prodrugs, disoproxil and alafenamide [ 73 ]. Open in a separate window. Figure 4. Nucleos (t)ide Analogues (NAs) approved for the treatment of hepatitis B [ 28, 73 ].
Jan 19, 2023 · Hepatitis B virus e antigen (HBeAg) is translated from an HBc reading frame and is an indicator of cccDNA replication. The rcDNA of HBV, on entering the cells, is converted into covalently closed circular DNA (cccDNA), which generates viral RNAs of different lengths due to the initiation of transcription from different promoters.
