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Thuốc chống loạn thần không điển hình (tiếng Anh: atypical antipsychotics - AAP, còn được gọi là thuốc chống loạn thần thế hệ thứ hai (second generation antipsychotics - SGAs )) là một nhóm thuốc chống loạn thần (thuốc chống loạn thần nói chung còn được gọi là thuốc an thần và thuốc an thần kinh điển hình ), mặc dù loại thuốc này thường được dùn...
Thuốc chống loạn thần, còn được gọi là thuốc an thần kinh hoặc thuốc an thần lớn, là một loại thuốc chủ yếu được sử dụng để quản lý rối loạn tâm thần (bao gồm ảo tưởng, ảo giác, hoang tưởng hoặc suy nghĩ rối loạn), chủ yếu trong tâm thần phân liệt và rối loạn lưỡng cực.
Antipsychotics, previously known as neuroleptics [1] and major tranquilizers, [2] are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought ), principally in schizophrenia but also in a range of other psychotic disorders.
- Clinical Uses
- Adverse Effects
- Potency
- Long-Acting Injectables
- History
- See Also
Typical antipsychotics block the dopamine 2 receptor (D2) receptor, causing a tranquilizing effect. It is thought that 60–80% of D2 receptors need to be occupied for antipsychotic effect. For reference, the typical antipsychotic haloperidol tends to block about 80% of D2 receptors at doses ranging from 2 to 5 mg per day. On the aggregate level, no ...
Adverse effects vary among the various agents in this class of medications, but common effects include: dry mouth, muscle stiffness, muscle cramping, tremors, EPS and weight gain. EPS refers to a cluster of symptoms consisting of akathisia, parkinsonism, and dystonia. Anticholinergics such as benztropine and diphenhydramine are commonly prescribed ...
Traditional antipsychotics are classified as high-potency, mid-potency, or low-potencybased on their potency for the D2 receptor: Prochlorperazine (Compazine, Buccastem, Stemetil) and Pimozide(Orap) are less commonly used to treat psychotic states, and so are sometimes excluded from this classification. A related concept to D2 potency is the concep...
Some typical antipsychotics have been formulated as a long-acting injectable (LAI), or "depot", formulation. Depot injections are also used on persons under involuntary commitmentto force compliance with a court treatment order when the person would refuse to take daily oral medication. This has the effect of dosing a person who doesn't consent to ...
The original antipsychotic drugs were happened upon largely by chance and then tested for their effectiveness. The first, chlorpromazine, was developed as a surgical anesthetic after an initial report in 1952. It was first used in psychiatric institutions because of its powerful tranquilizing effect; at the time it was advertised as a "pharmacologi...
May 8, 2024 · Antipsychotics, also known as neuroleptic medications, are drugs that target certain neurotransmitters to manage the symptoms of mental health conditions. Antipsychotics are...
Feb 26, 2023 · Antipsychotic Medications. Krutika Chokhawala; Lee Stevens. Author Information and Affiliations. Last Update: February 26, 2023. Go to: Continuing Education Activity. First-generation antipsychotics are dopamine receptor antagonists (DRA) and are known as typical antipsychotics.
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British Our review identified only five trials evaluating use of oral atypical antipsychotic drugs to treat the behavioural and psychological symptoms of dementia. British The prevalence of sexual dysfunction in men and women treated with antipsychotic drugs is high; however, the contribution of hyperprolactinaemia and secondary hypogonadism ...
