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1. www.mayoclinic.org › diseases-conditions › breastBreast cancer - Symptoms and causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › breast

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   Feb 10, 2024 · Signs and symptoms of breast cancer may include: A breast lump or thickened area of skin that feels different from the surrounding tissue. A nipple that looks flattened or turns inward. Changes in the color of the breast skin. In people with white skin, the breast skin may look pink or red.

2. www.ncbi.nlm.nih.gov › pmc › articlesTargeting the cell cycle in breast cancer: towards the next phase

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 11, 2018 · Different breast cancer subtypes exhibit different molecular alterations and dependencies on the cell cycle and its checkpoints [ 20 ]. In hormone-receptor (ER+) positive/HER2-negative “luminal” breast cancers, malignant cells generally retain dependence on estrogen for its mitogenic effects.

   • Author: KL Thu, I Soria-Bretones, TW Mak, DW Cescon
   • DOI: 10.1080/15384101.2018.1502567

   • Publish Year: 2018
   • Publication: Cell Cycle. 2018; 17(15): 1871-1885.

3. People also ask

   Why are breast cancer stem cells unique?

   • The mosaic of genetic alterations contributes to the singularity of breast cancer stem cells (BCSCs) and, ultimately, the response of breast cancer patients to treatment. The CSCs are defined conventionally by their ability to self-renew and differentiate into heterogeneous cell populations, some with no tumorigenic capacity.

   Breast cancers, mammary stem cells, and cancer stem cells

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/

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   What do we know about genetic alterations in breast cancer?

   • While decades of research have mapped out a compendium of genetic alterations in breast cancer and their potential function within signaling networks, there is still much to learn about pathway crosstalk, compensatory mechanisms, and the development of drug resistance.

   Deciphering breast cancer: from biology to the clinic: Cell

   www.cell.com/cell/fulltext/S0092-8674(23)00099-5

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   What are the characteristics of breast cancer?

   • ). Breast cancer comprises multiple biological entities characterized by heterogeneity in pathology, genomic alterations, gene expression, and the tumor microenvironment (TME), which collectively influence clinical behavior and treatment response.

   Deciphering breast cancer: from biology to the clinic: Cell

   www.cell.com/cell/fulltext/S0092-8674(23)00099-5

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4. pathology.jhu.edu › breast › types-of-breast-cancerTypes of Breast Cancer - Breast Pathology | Johns Hopkins ...

   pathology.jhu.edu › breast › types-of-breast-cancer

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   A type of laboratory test that can detect the proteins expressed by a cell. The test uses special antibodies (“immunostains”) that each binds to a particular protein in question; the immunostain will change the color of the tissue to show whether a protein is present.

5. www.cell.com › cell › fulltextDeciphering breast cancer: from biology to the clinic: Cell

   www.cell.com › cell › fulltext

   Mar 16, 2023 · Dynamic and multi-layered crosstalk between malignant and non-malignant cells within the TME plays a fundamental role in breast cancer initiation and progression, with tumor cells shaping their environment by reprogramming tissue-resident and recruited cells to support their survival, growth, and dissemination.

6. www.nature.com › articles › s41416/021/01328-7Breast cancer as an example of tumour heterogeneity and ...

   www.nature.com › articles › s41416/021/01328-7

   Apr 6, 2021 · Breast cancer is a highly heterogeneous disease that can be caused by a variety of distinct genetic alterations in mammary epithelial cells, leading to vastly different disease manifestations in ...

   • Author: Fabiana Lüönd, Stefanie Tiede, Gerhard Christofori

   • Publish Year: 2021

7. www.ncbi.nlm.nih.gov › pmc › articlesBreast cancers, mammary stem cells, and cancer stem cells ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 23, 2020 · Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations.

8. www.ucsfhealth.org › education › basic-facts-aboutBasic Facts About Breast Health: Breast Cancer Biology

   www.ucsfhealth.org › education › basic-facts-about

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   They have identified changes in certain genes within breast cells that can be linked to a higher risk for breast cancer. Breast cells contain a variety of genes that normally work cooperatively with a woman's natural hormones, diet, and environment to keep her breasts healthy.