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1. www.ncbi.nlm.nih.gov › pmc › articlesTargeting the cell cycle in breast cancer: towards the next phase

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 11, 2018 · In this review, we discuss both recently approved and investigational cell cycle targeting agents for the treatment of breast cancer, including cyclin dependent kinase 4/6 (CDK4/6) inhibitors in ER+ breast cancers and TTK protein kinase (TTK) and polo-like kinase 4 (PLK4) inhibitors in TNBCs.

2. www.cancer.org › gene-changesGenetic Mutations | Types of Mutations | American Cancer Society

   www.cancer.org › gene-changes

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   Inherited versus acquired gene mutations. Gene variants, including mutations, can be either inherited or acquired. An inherited gene mutation, as the name implies, is inherited from a parent, so it’s present in the very first cell (once the egg cell is fertilized by a sperm cell) that eventually becomes a person.

3. People also ask

   Why are breast cancer stem cells unique?

   • The mosaic of genetic alterations contributes to the singularity of breast cancer stem cells (BCSCs) and, ultimately, the response of breast cancer patients to treatment. The CSCs are defined conventionally by their ability to self-renew and differentiate into heterogeneous cell populations, some with no tumorigenic capacity.

   Breast cancers, mammary stem cells, and cancer stem cells

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/

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   Are breast cancer cells similar to stem cells?

   • Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors.

   Breast cancers, mammary stem cells, and cancer stem cells

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/

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   What is the cell of origin of breast cancer?

   • Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.

   Breast cancers, mammary stem cells, and cancer stem cells

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7586061/

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4. www.ncbi.nlm.nih.gov › pmc › articlesBreast cancers, mammary stem cells, and cancer stem cells ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 23, 2020 · Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations.

   • Author: Sebastien Taurin, Haifa Alkhalifa
   • DOI: 10.1016/j.neo.2020.09.009

   • Publish Year: 2020
   • Publication: Neoplasia. 2020 Dec; 22(12): 663-678.

5. www.cell.com › cell › fulltextDeciphering breast cancer: from biology to the clinic: Cell

   www.cell.com › cell › fulltext

   Mar 16, 2023 · Dynamic and multi-layered crosstalk between malignant and non-malignant cells within the TME plays a fundamental role in breast cancer initiation and progression, with tumor cells shaping their environment by reprogramming tissue-resident and recruited cells to support their survival, growth, and dissemination.

6. www.nature.com › articles › s41416/021/01328-7Breast cancer as an example of tumour heterogeneity and ...

   www.nature.com › articles › s41416/021/01328-7

   Apr 6, 2021 · Breast cancer is a highly heterogeneous disease that can be caused by a variety of distinct genetic alterations in mammary epithelial cells, leading to vastly different disease manifestations in ...

   • Author: Fabiana Lüönd, Stefanie Tiede, Gerhard Christofori

   • Publish Year: 2021

7. www.ncbi.nlm.nih.gov › pmc › articlesThe Cellular Origin and Evolution of Breast Cancer - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   In this review, we will discuss how the cell of origin may modulate breast cancer intratumoral heterogeneity (ITH) as well as the role of ITH in the evolution of cancer. The clonal evolution and the cancer stem cell (CSC) models, as well as a model that integrates clonal evolution with a CSC hierarchy, have all been proposed to explain the ...

8. www.mayoclinic.org › diseases-conditions › breastBreast cancer - Symptoms and causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › breast

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   Feb 10, 2024 · Breast cancer also can start in cells in the milk glands. These glands, called lobules, are designed to make breast milk. Cancer that happens in the lobules is called invasive lobular carcinoma. Other cells in the breast can become cancer cells, though this isn't common.