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  2. Feb 15, 2024 · 8 FDA-Approved Drugs for Weight Management. By Phuoc Anh (Anne) Nguyen, PharmD, MS, BCPS. Updated on February 15, 2024. Medically reviewed by Lindsay Cook, PharmD. Print. Table of Contents. View All. Xenical (Orlistat) Alli (Orlistat) Contrave (Bupropion-Naltrexone) Saxenda (Liraglutide) Qsymia (Phentermine-Topiramate)

    • Phentermine (Adipex-P and Lomaira) Phentermine is one of the most widely used prescription weight loss medications in the United States and has been around since the 1950s.
    • Qsymia (Phentermine and Topiramate) This popular weight loss pill contains phentermine combined with a migraine medication called topiramate. Research shows combining these two drugs may result in greater weight loss than either alone.
    • Contrave (Naltrexone and Bupropion) Contrave is another FDA-approved prescription-only weight loss medication that combines naltrexone and bupropion.
    • Orlistat (Xenical) Orlistat is another FDA-approved prescription weight loss medication in capsule form. You may be familiar with Orlistat’s over-the-counter version, Alli, available at a lower dose.
  3. Nov 8, 2023 · The F.D.A. approved Zepbound for people with obesity and for those who are overweight and have at least one obesity-related condition. Tirzepatide is already approved for diabetes under...

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    • Oral semaglutide. What it is: Oral semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It mimics the effects of GLP-1, a gut hormone that's involved in blood glucose (sugar) control, digestion, and appetite management.
    • Orforglipron. What it is: Orforglipron is an oral GLP-1 agonist. Unlike injectable GLP-1 agonists, it’s made of chemicals — not peptides (amino acid chains).
    • Danuglipron. What it is: Danuglipron is an oral GLP-1 pill. It works the same way as orforglipron. How it’s administered: Danuglipron is an oral tablet.
    • APH-012. What it is: APH-012 is an oral medicine that imitates the metabolic effects of gastric bypass (weight loss) surgery. It’s a glucose pill that’s designed to stimulate certain parts of your small intestine.
  5. Apr 1, 2024 · Some popular weight-loss pills are Contrave (naltrexone / bupropion), Qsymia (phentermine / topiramate ER), and phentermine (Adipex-P). Some clinical studies suggest that Qsymia is the most effective weight loss pill. However, it’s a controlled substance that may not be the best option for everyone.

  6. Oct 29, 2022 · Six weight-loss drugs have been approved by the U.S. Food and Drug Administration (FDA) for long-term use: Bupropion-naltrexone (Contrave) Liraglutide (Saxenda) Orlistat (Xenical, Alli) Phentermine-topiramate (Qsymia) Semaglutide (Wegovy) Setmelanotide (Imcivree)

  7. May 1, 2024 · In June 2021, the FDA approved semaglutide ( Wegovy ), a once-weekly injection, for weight loss in adults when used in combination with a healthy diet and routine exercise. Before its approval, semaglutide had made headlines when the manufacturer reported participants had lost 15% to 18% of their starting body weight during clinical trials.

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