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Jul 17, 2020 · Management of actinic keratoses includes lesion-directed treatments, such as cryotherapy and field-directed therapies. Field-directed therapies may have the potential to address subclinical damage, reduce AK recurrence rates and potentially reduce the risk of squamous cell carcinoma development.
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National Center for Biotechnology Information
- Role of Cpi-17 in Restoring Skin Homoeostasis in Cutaneous Field of Cancerization
Background. Cutaneous field of cancerization (CFC) is...
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- Photoprotection
- 5-Fluorouracil
- Photodynamic Therapy
- Imiquimod
- Chemical Peels
- Combined Treatments in The Clinic
- Oral Therapy
- Follow-Up and Monitoring
Since UV radiation is a tumor initiator and tumor promoter of cutaneous cancer and because animal models have demonstrated reduced precursor lesions when UV exposure is interrupted, the first step in the management of the patient with multiple AK and FC is rigorous sun protection . The sunscreens chosen should contain liposomal DNA-photolyase and h...
A recently published clinical trial showed that topical 5% fluorouracil (5-FU) was significantly more effective than imiquimod, methyl aminolevulinate-PDT (MAL-PDT) or ingenol mebutate at 12 months after the end of treatment for multiple AK lesions . Similar findings were shown in a network meta-analysis . Prophylactic treatment with topical 5-FU i...
Photodynamic therapy is based on the activation of a photosensitizing agent with subsequent release of reactive oxygen species and tissue destruction. A prodrug (aminolevulinic acid [ALA] or MAL [M-ALA]) is topically applied to the skin 1–3 h prior to visible-spectrum daylight, red light or blue light treatment . PDT is an effective FC treatment an...
Imiquimod is an effective form of immunotherapy for the treatment of AK and FC . It is an immune response modifier that activates immune cells via toll-like receptor 7, initiating a cascade leading to the induction of cytokines, such as interferon alfa, interferon gamma, and interleukin 12, which promote a T helper 1 (TH1) immune response .
Chemical peels (CP) have been used to treat diverse aesthetic and medical skin conditions. Topical exfoliative agents, alone or in combination, are used to induce controlled cutaneous injury, ultimately resulting in epidermal turnover and collagen regeneration . CP are widely used in cosmetics to improve the appearance of photoaged skin by reducing...
Pearls
1. (1) Use a repairing cream immediately after the procedure as a “fire extinguisher” for a cooling effect. We suggest keeping these creams in the refrigerator or, alternatively, to immersing them in ice water before the procedure. Products containing triterpenes of gotu kola with rosehip oil are the best options [33, 45]. 2. (2) Use non-ablative energy devices, such as intense pulsed light or the non-ablative erbium:glass fiber 1550 nm laser system, as part of the treatment for photodamaged...
Pearls
1. (1) Nutricosmetics with Polypodium leucotomus allow better tolerance to sun exposure and increase the minimum erythemal dose (MED) . Nutricosmetics can be an excellent option in patients who do outdoor activities as an adjuvant to topical photoprotection in susceptible populations, as they restore the intracellular redox status and increase the MED, inducing photoadaptation and photo-immunoprotection. P. leucotomos extract decreases lipid peroxides and neutralizes superoxide anions and...
Non-invasive techniques, such as photography, dermoscopy and reflectance confocal microscopy, and validated severity scores such as the Actinic Keratosis Area and Severity Index (AKASI), can be used to assess the severity of AK and may help in the follow-up and monitoring treatment responses [50, 51].
- Jaime Piquero-Casals, Daniel Morgado-Carrasco, Yolanda Gilaberte, Rubén Del Rio, Antonio Macaya-Pasc...
- 2020
Jun 7, 2021 · Treatment options for AK include topical medications, photodynamic therapy, cryosurgery, and laser ablation. Objective. This executive summary provides a synopsis of the 18 evidence-based recommendations for the treatment of AK detailed in the Guidelines of Care for the Management of Actinic Keratosis. Methods.
- Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Est...
- 2021
If you have one or more actinic keratoses (AKs), it’s a sign of skin damage that puts you at a high risk for developing skin cancer. Identifying and treating these precancerous lesions helps you reduce that risk.
May 30, 2019 · Field-directed treatments for multiple actinic keratoses. Cryotherapy, or the targeted use of liquid nitrogen, is commonly used to treat individual lesions. But what if there are many actinic keratoses scattered all over the face or hands?
- hhp_info@health.harvard.edu
Mar 7, 2024 · There are multiple effective treatment options for actinic keratosis (AK), including destructive therapies (eg, cryosurgery, surgery, dermabrasion, photodynamic therapy [PDT]), topical medications (eg, topical fluorouracil, imiquimod, topical tirbanibulin, diclofenac), and field ablation treatments (eg, chemical peels, laser resurfacing).
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Aug 17, 2023 · Field-Directed Treatments: Treat multiple, widespread, and subclinical actinic keratoses that may be within an area of chronic sun damage Dermabrasion: Dermabrasion involves the mechanical removal of the superficial layers of the skin in areas affected by actinic damage.
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