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Quinidine, mexiletine, and procainamide
- Treatment of Myotonia Congenita in Dogs Treatment options for myotonia include quinidine, mexiletine, and procainamide. All three of these are medications that stabilize the membrane and have been found to reduce the symptoms in dogs with this condition.
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Treatment of Myotonia Congenita in Dogs Treatment options for myotonia include quinidine, mexiletine, and procainamide. All three of these are medications that stabilize the membrane and have been found to reduce the symptoms in dogs with this condition.
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- Summary
- Symptoms and Identification
- Affected Breeds
- Treatment
- Veterinary Cost
- Prevention
This rare disease, more aptly termed "myotonia congenita," affects the muscles by allowing the continuous contraction of muscle fibers. A painful, hereditary condition, myotonia is the result of chloride channel malformations in dogs, though a small number of cats have also been found to suffer it. The inability of the chloride channels (which allo...
Dogs with myotonia exhibit a stiff gait, experience trouble when rising, often suffer swollen tongues and may have difficulty swallowing. Young dogs start to show symptoms as early as of a few weeks of age. Muscle biopsy and electromyography (or "EMG," a study of electrical impulses in the muscles) have been shown to be helpful in diagnosing the pr...
The following breeds are predisposed: 1. Chow-chows 2. Staffordshire Terriers 3. Great Danes 4. Miniature Schnauzers
Procainamide, a drug used to treat heart arrhythmias, is an option that has been found to reduce the symptoms in many affected dogs. Apart from this approach, nothing has been found to be effective, including (to this date) treatment of the underlying disease in those who have "acquired" (non-congenital) forms of myotonia. Yet few dogs will ever be...
The cost of diagnosis is the largest expense owners will face. For muscle biopsies and neurologist-facilitated EMGs, the costs may range from the high hundreds to the low thousands of dollars. The cost of the drug itself is not usually considered a major factor.
Prevention of congenital myotonia is achieved primarily through testing of affected breeds and removing carriers or affected patients from the breeding pool through spay and neuter. A campaign is currently underway by the University of Pennsylvania to test all miniature Schnauzers intended for breeding to completely eliminate this problem in this b...
Treatment. There is no treatment currently for this condition, but physical therapy can be beneficial. What to do if your dog is at risk Actions. Learning physical therapy techniques from your veterinarian may be beneficial at home. Genetic Information. This mutation was first described in the Miniature Schnauzer.
Skeletal muscle chloride channelopathies, also known as myotonia congenita (MC), are subdivided based on their mode of inheritance: autosomal dominant or Thomsen myotonia congenita (TMC) 12 and autosomal recessive or Becker myotonia congenita (BMC). 13,14 Both TMC and BMC cause muscle stiffness that can be improved with repetitive muscle activity, called the warm-up phenomenon. 15 BMC is ...
- Bas C. Stunnenberg, Samantha LoRusso, W. David Arnold, Richard J. Barohn, Stephen C. Cannon, Bertran...
- 10.1002/mus.26887
- 2020
- 2020/10
Dec 20, 2005 · Myotonia Congenita is a hereditary, skeletal muscle disorder. Mytonic puppies exhibit clinical signs at a few weeks of age because their muscles are hyperexcitable and contract easily.
May 30, 2017 · The nondystrophic myotonic syndromes are caused by conventional point mutations or deletions in the genes that encode skeletal muscle chloride or sodium channels.47 These include myotonia congenita, caused by mutations in the skeletal muscle chloride channel gene, CLCN1, and paramyotonia congenita, hyperkalemic periodic paralysis (HyperPP), and ...
What to Watch For: Dogs with myotonia exhibit a stiff gait, experience trouble when rising, often suffer swollen tongues and may have difficulty swallowing. Young dogs start to show symptoms as early as of a few weeks of age. Diagnosis of Myotonia in Dogs.
