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Mar 4, 2022 · Von Willebrand disease (VWD) is the most common hereditary bleeding disorder in dogs and people, and the trait has been identified in many other species. The disease is heterogeneous, caused by a variety of defects in von Willebrand factor (VWF) protein that influence bleeding severity and complicate clinical diagnosis and management.
Von Willebrand Disease (vWD) is an inherited bleeding disorder that makes it difficult for blood to clot. It is the most common inherited bleeding disorder in dogs, and it can be seen more frequently in certain breeds, such as Doberman Pinschers.
- Study Population
- Vwdi Genotyping Results
- Bleeding Tendencies
- VWF Serum Concentration
87 Kromfohrländer composed of 62% females and 38% males including purebred Kromfohrländer, as well as F1, F2 and F3 so called project dogs from outcross matings with Dansk-Svensk Gårdshund (Danish–Swedish Farmdog) as part of the outcross program in the ProKromfohrländer e. V. Germany were included in this study. Of all study dogs 73.5% were purebre...
For genetic testing, study dogs were categorized in three different groups, wild-type (WT/WT), heterozygous (WT/MUT) and homozygous (MUT/MUT) for the vWDI mutation. Based on the genotyping data for the G > A transversion in the last nucleotide of exon 43 coding for von Willebrand factor (Fig. 2), 19.5% were wild-type (WT/WT), 65.5% were heterozygou...
Information on bleeding tendencies was based on owner questionnaires which were provided for all study dogs with an exception of 3 dogs. Questions were primarily related to preceding surgeries or prolonged bleeding times for example during second dentition, heat, birth, implantations for chemical castration, injuries, or prolonged bleeding time aft...
In addition to the genetic status of vWDI, von Willebrand factor serum levels were determined during health monitoring and results were forwarded by ProKromfohrländer e.V. or by dog owners or breeders to our laboratory. vWF serum levels were available from 64 dogs out of 87. The vWDI concentration in wild-type dogs (WT/WT) ranged from 28 to 137%. F...
- Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer, Anja M. Geretschlaeger
- 2019
Jan 1, 1988 · Type 2 Von Willebrand disease (VWD) is a severe coagulopathy occurring in the Deutsch-Drahthaar dog (or German Wirehaired Pointer, DD/GWP). Recently, a causative recessive mutation has been identified, and a DNA test is now available for individual screening.
- Gary S. Johnson, Mark A. Turrentine, Karl H. Kraus
- 1988
Abstract. Objective: To develop an assay to measure canine von Willebrand factor (vWF):collagen-binding activity (CBA) to screen for type 2 von Willebrand disease (vWD) in dogs. Sample population: 293 plasma samples submitted for analysis of canine vWF antigen (vWF:Ag) and 12 control plasma samples from dogs with inherited type 2 or 3 vWD.
- Elizabeth Peet Sabino, Hollis N Erb, James L Catalfamo
- 2006
Oct 1, 2009 · Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency.
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Jan 1, 2010 · The aims of the current study were to assess the prevalence of von Willebrand disease (vWD) in dogs from the region of Botucatu, São Paulo State, Brazil, and to evaluate laboratory tests to diagnose this disease. The study included 350 dogs of various ages, different breeds, and both sexes.
