Search results
von Willebrand disease (VWD) represents the most common inherited bleeding disorder (Lillicrap 2013). It is caused by quantitative or qualitative reductions in plasma von Willebrand factor (VWF) (Leebeek and Eikenboom 2016).
- Helen Fogarty, Dearbhla Doherty, James S. O'Donnell, James S. O'Donnell
- 10.1111/bjh.16681
- 2020
- 2020/11
Dec 22, 2017 · Abstract. von Willebrand disease (vWD) is the most common inherited coagulopathy in dogs, particularly in Doberman Pinschers. We developed a pyrosequencing-based assay to estimate the frequency of the c.7437G>A mutation associated with vWD type 1 in the Doberman Pinscher population of Buenos Aires, Argentina.
- Julian Alejandro Crespi, Laura Soledad Barrientos, Guillermo Giovambattista
- 10.1177/1040638717750429
- 2018
- J Vet Diagn Invest. 2018 Mar; 30(2): 310-314.
People also ask
What is von Willebrand disease in dogs?
Can a deficiency of vWF cause von Willebrand disease?
Do Doberman Pinschers have von Willebrand disease?
What is the prevalence of von Willebrand disease (vWD)?
- Overview
- Causes
- Breed Predisposition
- Clinical Signs
- Diagnosis
- Treatment
- Outcome
- Prevention
- Genetics
Von Willebrand Disease (vWD) is an inherited bleeding disorder that makes it difficult for blood to clot. It is the most common inherited bleeding disorder in dogs, and it can be seen more frequently in certain breeds, such as Doberman Pinschers. Dogs with vWD may show signs of bleeding, such as skin bruising, bleeding from the gums or nose, and ex...
A protein called the von Willebrand Factor (vWF) plays an important role in clot formation. For dogs with vWD, this protein can be reduced, dysfunctional or absent all together. This results in prolonged bleeding, because it takes longer for dogs with vWD to form clots. There are three types of vWD, each defined by either a lack of vWF or poorly fu...
Some of the breeds predisposed to vWD include, but are not limited, to the following: 1. Type I:Doberman Pinschers, Pembroke Welsh Corgis, Poodles, Bernese Mountain Dogs, Irish Setters, West Highland White Terriers 2. Type II:German Wirehaired and Shorthaired Pointers 3. Type III:Scottish Terriers, Kooikerhondje, Shetland Sheepdogs, Chesapeake Bay ...
The clinical signs may vary depending on the amount of functional vWF present. Some dogs may have no obvious signs. The most common signs include: 1. Easy bruising 2. Skin bleeding, even from minor wounds 3. Bleeding from gums (e.g. while teething or chewing on toys) 4. Bleeding from nose, bladder (blood-tinged urine), vagina, or GI tract (blood in...
Your veterinarian may perform bloodwork to rule out other forms of bleeding disorders, followed by a simple test that times how quickly a blood clot forms (the buccal mucosal bleeding time, or BMBT). If this test shows delayed clot formation, and the rest of the testing comes back normal, then your veterinarian will want to perform another blood te...
There are some IV medications or blood products that can be given before necessary surgical procedures or to control other types of bleeding. Examples include desmopressin acetate (not used in Type III vWD), cryoprecipitate or fresh frozen plasma. These treatments work by temporarily increasing the amount of vWF in the blood. Your veterinarian may ...
There is no cure for vWD. The prognosis will depend on the type of vWD, which correlates to the dog’s risk of bleeding. With proper management, many dogs with vWD can have a normal lifespan. Strategies can include avoiding cosmetic surgeries, giving proper medications prior to necessary surgeries and avoiding certain medications that can further af...
Because vWD is inherited, dogs suspected of having (or carrying) vWD should not be used for breeding without genetic testing and careful consideration of mate selection. DNA screening is available for several dog breeds. If genetic testing determines that a dog at-risk for vWD (e.g. carrying two copies of the variant), they may be subsequently test...
VWD can be caused by several different genetic variants in the vWF gene. Type I vWD, which is the most common, is found in many breeds, and it has one known variant in the vWF gene. This variant is recessively inherited, which means that a dog is at-risk of developing vWD if they have two copies of the variant. However, it is possible for dogs that...
May 16, 2019 · Research. Open access. Published: 16 May 2019. vWDI is inherited in an autosomal dominant manner with incomplete penetrance, in the Kromfohrländer breed. Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer & Anja M. Geretschlaeger. Canine Genetics and Epidemiology 6, Article number: 3 ( 2019 ) Cite this article. 6617 Accesses. 4 Citations.
- Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer, Anja M. Geretschlaeger
- 2019
Mar 4, 2022 · Summary. Von Willebrand disease (VWD) is the most common hereditary bleeding disorder in dogs and people, and the trait has been identified in many other species. The disease is heterogeneous, caused by a variety of defects in von Willebrand factor (VWF) protein that influence bleeding severity and complicate clinical diagnosis and management.
Dec 6, 2019 · Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD).
May 12, 1997 · Project Summary. This research was responsible for the development of five genetic tests for von Willebrand's disease (vWD). vWD is an inherited bleeding disorder that is seen frequently in Doberman Pinschers. In Dobermans, it is autosomal recessive (affected dogs receive one mutated gene from each parent). Researchers determined that Dobermans ...
