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Von Willebrands. In 1926 a Finnish physician, Dr von Willebrand, discovered a clotting disorder. His primary research led to the discovery of a deficiency of a particular protein (the carrier protein for factor VIII), which was responsible for this clotting disorder. He discovered that though there seemed to be enough platelets, they were not ...
Von Willebrand’s disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs. It is caused by a lack of von Willebrand factor (vWF), which plays an essential role in the blood clotting process. Normally the body responds to an injury causing bleeding through a complex defense system.
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What is von Willebrand disease in Doberman Pinschers?
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What is von Willebrand disease?
Mar 13, 2004 · Von Willebrand's disease, like hemophilia A, is an inherited blood clotting defect and breeds at high risk should be screened before being allowed to breed. Breeds routinely tested are Doberman Pinscher, Golden Retriever, Shetland Sheepdog, Rottweiler, Miniature Schnauzer, German Shepherd, German Short-Haired Pointer, Standard Poodle, and ...
- Background
- Clinical Signs
- Treatment
- Laboratory Diagnosis
- Inheritance
- VWD Screening: Breed Summaries
von Willebrand Disease(abbreviated vWD) is an inherited bleeding disorder caused by lack of von Willebrand factor protein (vWF). This protein circulates in the blood stream and must be present at the site of blood vessel injury in order to control bleeding from that vessel. Von Willebrand disease is a distinct disorder, it is not hemophilia.
Clinical signs of vWD range from a mild to severe bleeding tendency. Dogs may "carry" the vWD trait without expressing a bleeding tendency. Severe vWD causes spontaneous bleeding from the nose, mouth, and urinary, reproductive or intestinal tracts. Uncontrollable bleeding may occur after surgery. Dewclaw removal and teething may cause excessive ble...
Treatment of a severe bleeding episode requires transfusion of canine blood products. Plasma products can be transfused pre-operatively to prevent surgical hemorrhage. Desmopressin acetate (DDAVP) can also be used to improve hemostasis in dogs with mild subtype (Type 1) VWD. Bleeding from minor injuries may be controlled using sutures, bandages or ...
Laboratory diagnosis of VWD is most often based on results of von Willebrand factor antigen assay (abbreviated VWF:Ag). This test measures the amount or concentration of VWF in a blood sample. The Comparative Coagulation Laboratory reports each dog's result as %VWF:Ag compared to a 100% standard. Dogs having low plasma VWF:Ag (below 50%) are predic...
Hereditary VWD is an autosomal trait, therefore males and females transmit and express the trait with equal frequency. All males and females have 2 VWF genes, one inherited from dam and one from sire. In many breeds, the presence of 1 abnormal VWF gene appears sufficient to cause abnormal and variable bleeding, an expression pattern referred to as ...
The Comparative Coagulation Laboratory’s submissions for canine VWF:Ag assay were reviewed over a 3-year period (2016 to 2019). The VWF:Ag values for the most commonly tested dogs are summarized by breed in the following graphs:
- 0 to 49
- 70 to 180
- 50 to 69
von Willebrand disease has been found only in a couple of the Dobermans that DRNM has taken in over the years, less than 1% of our rescues. In both cases, the dogs were not severely affected by the disease and have lived normal lives without incident.
The main symptom is excessive bleeding after an injury or surgery. Other symptoms include nosebleeds, bleeding gums, or bleeding in the stomach or intestines. There is no cure, and a blood transfusion from the blood of normal dogs is currently the only treatment. However, most dogs with von Willebrand's disease can lead normal lives.
1. Brief description. Von Willebrand disease (vWD) is a common abnormality of the process by which blood clots. In Doberman pinschers the problems caused by vWD are relatively mild. Excessive bleeding may occur in some circumstances, for example when affected animals are teething or in season.
