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von Willebrand disease is caused by either a quantitative or qualitative defect in von Willebrand factor (VWF). Patients may have extensive mucosal bleeding (because of plate-let dysfunction) and prolonged bleeding after surgery (because of factor VIII deficiency).
The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
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Does von Willebrand disease cause bleeding events during pregnancy and childbirth?
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What is von Willebrand factor (vWF) and FVIII?
Does von Willebrand factor/factor VIII concentrate in the treatment of von Wille brand disease?
VWD is a genetic disorder caused by a missing or defective clotting protein in the blood called von Willebrand factor (VWF). VWF is important because it carries and protects another clotting factor in the blood – factor VIII. Without VWF, factor VIII becomes rapidly destroyed in the bloodstream/circulation, resulting in low factor VIII levels.
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von Willebrand disease is the most prevalent inherited bleeding disorder, afecting up to 1.3% of the population (American College of Obste-tricians and Gynecologists [ACOG], 2013). It is caused by a defect or deficiency of the von Wille-brand factor, which is located on chromosome 12 (Pacheco et al., 2010). The von Willebrand factor.
Von Willebrand disease (vWD) is an inherited bleeding disorder of von Willebrand factor (vWF) causing decreased platelet binding. In the laboring patient, this may predispose to postpartum hemorrhage or bleeding after neuraxial anesthesia, possibly leading to an epidural hematoma.
Jan 1, 2017 · Article PDF Available. Management of von willebrand disease in pregnancy. January 2017. CHRISMED Journal of Health and Research 4 (3):225. DOI: 10.4103/cjhr.cjhr_16_17. License. CC BY-NC-SA....
Von Willebrand disease is a prevalent condition in females of childbearing age, and during pregnancy, it is associated with a higher risk of postpartum bleeding, exposure to massive transfusion protocols, pulmonary edema, acute renal injury, postpartum bleeding-related maternal mortality, and transfusion-related complications .
