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Oct 26, 2021 · The usual cause of von Willebrand disease is an inherited abnormal gene that controls von Willebrand factor — a protein that plays a key role in blood clotting. When you have low levels of this protein or it doesn't work as it should, small blood cells called platelets cannot stick together properly nor attach themselves normally to the blood ...
May 15, 2024 · Key points. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9, 17, 27, 31, treatment options should be planned at the beginning of pregnancy.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
Jun 22, 2022 · What are the symptoms of von Willebrand disease? Many people with von Willebrand disease have the condition, but don’t have symptoms or have mild symptoms. People who have a more severe form of the condition may have the following symptoms: Nosebleeds: These are nosebleeds that last longer than 10 minutes and happen five or more times a year.
May 20, 2019 · Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also F...
- Giancarlo Castaman, Paula D. James
- 2019
Key Points. Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. VWD is the most common bleeding disorder. Signs of VWD include nosebleeds, easy bruising, heavy menstrual bleeding, and longer than normal bleeding after injury, surgery, dental work, or childbirth.
Reynen E, James P. Von Willebrand disease and pregnancy: a review of evidence and expert opinion. Semin Thromb Hemost . 2016;42(7):717-723. Stoof SC, van Steenbergen HW, Zwagemaker A, et al. Primary postpartum haemorrhage in women with von Willebrand disease or carriership of haemophilia despite specialised care: a retrospective survey.
