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The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
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Author manuscript; available in PMC 2020 Nov 2. Published in...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
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May 15, 2024 · Key points. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
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What is von Willebrand disease (vWD)?
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What is von Willebrand factor (vWF) and FVIII?
Von Willebrand disease (VWD) is a clotting disorder characterized by a quantitative or qualitative deficiency of the Von Willebrand factor (VWF) [ 1 ]. Synthesized in endothelial cells and megakaryocytes, VWF plays a key role in primary and secondary hemostasis through its interaction with various platelet adhesion and aggregation receptors.
1. Do you have a blood relative who has a bleeding disorder, such as von Willebrand disease or hemophilia? 2.
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Jan 1, 2022 · Von Willebrand disease (VWD) is a common bleeding disorder that typically manifests with mucosal bleeding. 1 Although women and men are equally likely to be affected, women with VWD are more likely to have bleeding symptoms related to the high prevalence of heavy menstrual bleeding (HMB).
- 10.1182/bloodadvances.2021005589
- 2022/01/01
- Blood Adv. 2022 Jan 11; 6(1): 228-237.
von Willebrand disease (VWD) is the most common inherited bleeding disorder. VWD is caused by deficiencies in von Willebrand factor (VWF), a critical adhesive haemostatic protein. This review provides an overview of VWD diagnosis and treat-ment, special considerations in treating women with VWD, and current genomic ap-proaches to VWD.
Now known as von Willebrand disease In 1926, Erik von Willebrand first de- (VWD), this disorder is caused by either scribed a familial bleeding disorder in a quantitative or qualitative defect in von which symptoms were more severe in Willebrand factor (VWF). The preva-children and young women.
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